International Journal of Clinical Pediatric Dentistry

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VOLUME 9 , ISSUE 3 ( July-September, 2016 ) > List of Articles

REVIEW ARTICLE

Evaluation of Role of Myofibroblasts in Oral Cancer: A Systematic Review

Harjeet K Sekhon, Keya Sircar, Gurbani Kaur, Muneet Marwah

Citation Information : Sekhon HK, Sircar K, Kaur G, Marwah M. Evaluation of Role of Myofibroblasts in Oral Cancer: A Systematic Review. Int J Clin Pediatr Dent 2016; 9 (3):233-239.

DOI: 10.5005/jp-journals-10005-1370

License: CC BY-NC 4.0

Published Online: 01-12-2010

Copyright Statement:  Copyright © 2016; The Author(s).


Abstract

Aim: To conduct a systematic review on the role of myofibroblasts in progression of oral cancer. The myofibroblast is essential for the integrity of the mammalian body by virtue of its role in wound healing, but it also plays a negative role due to their role in promoting tumor development. Settings and design: Systematic review. Materials and methods: Bibliographic searches were conducted in several electronic databases using all publications in PubMed, PubMed central, EMBASE, CancerLit, Google scholar, and Cochrane CCTR between 1990 and June 2015. Results: The search of all publications from various electronic databases revealed 1,371 citations. The total number of studies considered for systematic review was 43. The total number of patients included in the studies was 990. Conclusion: Myofibroblasts are a significant component in stroma of oral cancer cases, though not identified in all cases. This systematic review shows that clinical, pathological, and immunohistochemistry tests have correlated the presence of high myofibroblast count in oral cancer cell stroma. Key Messages: Myofibroblasts play a significant role in oral cancer invasion and progression. Various studies have demonstrated their association with oral cancer. This review tends to highlight their role in the pathogenesis of oral cancer over the decade.


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  1. Eyden B. The myofibroblast in health and disease. Rev Esp Patol 2008;41(1):3-10.
  2. Derek R, Paraic AK, Mina JB. Fibrosis and cancer: myofibroblast come also from epithelial cells via EMT? J Cell Biochem 2007 Jul 1;101(4):830-839.
  3. Powell WD, Miffin RC, Valentich JD, Crowse SE, Saada JI, West AB. Myofibroblasts: I. Paracrine cells important in health and disease. Am J Physiol 1999 Jul;277(1 Pt 1):C1-C9.
  4. Powell DW. Myofibroblasts: paracrine cells important in health and disease. Trans Am Clin Climatol Assoc 2000;111: 271-292.
  5. Desmouliere A, Darby IA, Gabbiani G. Normal and pathological soft tissue remodeling: role of the myofibroblast, with special emphasis on liver and kidney fibrosis. Lab Invest 2003 Dec;83(12):1689-1707.
  6. Gabbiani G, Ryen GB, Majno G. Presence of modified fibroblast in granulation tissue and their possible role in wound contraction. Experientia 1971 May;27(5):549-550.
  7. Kujan O, Glenny MA, Duxbury J, Thakker N, Sloan P. Evaluation of screening strategies for improving oral cancer mortality: a Cochrane systematic review. J Dent Educ 2005 Feb;69(2):255-265.
  8. Seemayer TA, Lagacé R, Schurch W, Thelmo WL. The myofibroblast: biologic, pathologic and theoretical considerations. Pathol Annu 1980;15(Pt 1):443-470.
  9. Walter S, Gabbiani G, Thomas AS. The myofibroblast a quarter century after its discovery. Am J Surg Pathol 1998 Feb;22(2):141-147.
  10. Lagacé R, Schürch W, Seemayer TA. Myofibroblasts in the soft tissue sarcomas. Virchows Arch A Pathol Anat Histol 1980;389(1):1-11.
  11. Seemayer TA, Lagacé R, Schurch W. On the pathogenesis of sclerosis and nodularity in nodular sclerosing Hodgkin's disease. Virchows Arch A Pathol Anat Histol 1980;385(3): 283-291.
  12. Seemayer TA, Lagacé R, Schurch W, Tremblay G. Myofibroblasts in the stroma of invasive and the metastatic carcinoma: a possible host response to neoplasia. Am J Surg Pathol 1979 Dec;3(6):525-533.
  13. Angadi PV, Kale AD, Hallikerimath S. Evaluation of myofibroblasts in oral submucous fibrosis: correlation with disease severity. J Oral Pathol Med 2011 Mar;40(3):208-213.
  14. Gabbiani G. The evolution of the myofibroblast concept: a key cell for wound healing and fibrotic diseases. G Gerontol 2004;52:280-282.
  15. Clarke M, Oxman AD. Cochrane reviewers' handbook 4.1.6. The Cochrane library. Oxford: Update Software; 2003 (updated quarterly).
  16. Moher D, Liberati A, Tetzlaft J, Altman DG, PRISMA Group. Preferred reporting items for systematic reviews and meta-analysis: the PRISMA statement. Ann Intern Med 2009 Aug 18;151(4):264-269.
  17. Zidar N, Gale N, Kambic V, Fischinger J. Proliferation of myofibroblasts in the stroma of epithelial hyperplastic lesions and squamous carcinoma of the larynx. Oncology 2002;62(4):381-385.
  18. Barth PJ, Schenck zu Schweinsberg T, Ramaswamy A, Moll R. CD34+ fibrocytes, alpha-smooth muscle antigen-positive myofibroblasts, and CD117 expression in the stroma of invasive squamous cell carcinomas of the oral cavity, pharynx, and larynx. Virchows Arch 2004 Mar;444(3):231-234.
  19. Lewis MP, Lygoe KA, Nystrom ML, Anderson WP, Speight PM, Marshall JF, Thomas GJ. Tumor-derived TGF-beta1 modulates myofibroblast differentiation and promotes HGF/ SF-dependent invasion of squamous carcinoma cells. Br J Cancer 2004 Feb 23;90(4):822-832.
  20. Vered M, Shohat I, Buchner A, Dayan D. Myofibroblasts in the stroma of odontogenic cysts and tumors can contribute to variations in the biologic behavior of lesions. Oral Oncol 2005 Nov 4;41(10):1028-1033.
  21. Kellermann MG, Sobral LM, Da Silva SD, Zecchin KG, Graner E, Lopes MA. Myofibroblasts in the stroma of oral squamous cell carcinoma is associated with poor prognosis. Histopathology 2007 Dec;51(6):849-853.
  22. Kellermann MG, Sobral LM, Da Silva SD, Zecchin KG, Graner E, Lopes MA, Kowalski LP, Coletta RD. Mutual paracrine effects of oral squamous cell carcinoma cells and normal oral fibroblasts: induction of fibroblast to myofibroblast transdifferentiation and modulation of tumor cell proliferation. Oral Oncol 2008 May;44(5):509-517.
  23. Vered M, Allon I, Buchner A, Dayan D. Stromal myofibroblasts accompany modification in the epithelial phenotype of tongue dysplastic and malignant lesions. Cancer Microenviron 2009 Dec;2(1):49-57.
  24. Franz M, Spiegel K, Umbreit C, Richter P, Codina-Canet C, Berndt A, Altendorf-Hofmann A, Koscielny S, Hyckel P, Kosmehl H, et al. Expression of Snail is associated with myofibroblast phenotype development in oral squamous cell carcinoma. Histochem Cell Biol 2009 May;131(5):651-660.
  25. Kawashiri S, Tanaka A, Noguchi N, Hase T, Nakaya H, Ohara T. Significance of stromal desmoplasia and myofibroblast appearance at the invasive front in squamous cell carcinoma of the oral cavity. Head Neck 2009 Oct;31(10):1346-1353.
  26. Etemad-Moghadam S, Khalili M, Tirgary F, Alaeddini M. Evaluation of myofibroblasts in oral epithelial dysplasia and squamous cell carcinoma. J Oral Pathol Med 2009 Sep;38(8):639-643.
  27. Franz M, Wolheim A, Richter P, Umbreit C, Dahse R, Driemel O, Hyckel P, Virtanen I, Kosmehl H, Berndt A. Stromal laminin chain distribution in normal, hyperplastic and malignant oral mucosa: relation to myofibroblast occurrence and vessel formation. J Oral Pathol Med 2010 Apr;39(4):290-298.
  28. Seifi S, Shafahi S, Shafigh E, Sahabi SM, Ghasemi H. Evaluation for the presence of -SMA positive myofibroblasts in oral squamous cell carcinomas, and oral epithelial dysplasia and hyperkeratosis. Asian Pac J Cancer Prev 2010;11(2): 359-364.
  29. Sobral LM, Bufalino A, Lopes MA, Graner E, Salo T, Coletta RD. Myofibroblasts in the stroma of oral cancer promote tumorigenesis via secretion of activin A. Oral Oncol 2011 Sep;47(9):840-846.
  30. Salgueiredo-Giudice F, Fornias-Sperandio F, Martins-Pereira E, da Costa dal Vechio AM, de Sousa SC, dos Santos-Pinto-Junior D. The immunohistochemical profile of oral inflammatory myofibroblastic tumors. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011 Jun;111(6):749-756.
  31. Sridhara SU, Choudaha N, Kasetty S, Joshi PS, Kallianpur S, Tijare M. Stromal myofibroblasts in nonmetastatic and metastatic oral squamous cell carcinoma: an immunohisto-chemical study. J Oral Maxillofac Pathol 2013 May-Aug;17(2):190-194.
  32. Lúcio PS, Cavalcanti AL, Alves PM, Godoy GP, Nonaka CF. Myofibroblasts and their relationship with oral squamous cell carcinoma. Braz J Otorhinolaryngol 2013 Jan-Feb;79(1):112-118.
  33. Angadi PV, Patil PV, Kale AD, Hallikerimath S, Babji D. Myofibroblast presence in apparently normal mucosa adjacent to oral squamous cell carcinoma associated with chronic tobacco/areca nut use: evidence for field cancerization. Acta Odontol Scand 2014 Oct;72(7):502-508.
  34. Routray S, Sunkavali A, Bari KA. Carcinoma-associated fibroblasts, its implication in head and neck squamous cell carcinoma: a mini review. Oral Dis 2014 Apr;20(3):246-253.
  35. Pinisetti S, Manyam R, Suresh B, Aparna V. Myofibroblasts in oral lesions: a review. J Oral Maxillofac Pathol 2014 Jan-Apr;18(1):52-57.
  36. Rao KB, Malathi N, Narashiman S, Rajan ST. Evaluation of myofibroblasts by expression of alpha smooth muscle actin: a marker in fibrosis, dysplasia and carcinoma. J Clin Diagn Res 2014 Apr;8(4):ZC14-ZC17.
  37. Radisky DC, Kenny PA, Bissell JB. Fibrosis and cancer: myofibroblast come also from epithelial cells via EMT? J Cell Biochem 2007 Jul 1;101(4):830-839.
  38. Phan SH. Biology of fibroblasts and myofibroblast. Proc Am Thorac Soc 2008 Apr 15;5(3):334-337.
  39. Thode C, Jorgensen TG, Dabelsteen E, Mackenzie I, Dabelsteen S. Significance of myofibroblasts in oral squamous cell carci-noma. J Oral Pathol Med 2011 Mar;40(3):201-207.
  40. Wever OD, Mareel M. Role of tissue stroma in cancer cell invasion. J Pathol 2003 Jul;200(4):429-443.
  41. Orimo A, Tomioka Y, Shimizu Y. Cancer associated myofibroblasts possess various growth factors to promote endometrial tumor progression. Clin Cancer Res 2001 Oct;7(10):3097-3105.
  42. Hay ED. Organization and fine structure of epithelium and mes-enchyme in the developing chick embryo. In: Fleischmajer R, Billingham RE, editors. Epithelial-mesenchymal interactions. Baltimore (MD): Williams and Wilkins; 1968. p. 31-55.
  43. Hinz B. The myofibroblast, one function, multiple origins. Am J Pathol 2007 Jun;17(6):1807-1816.
  44. Iwasaki H, Isayama T, IChiki T, Kikuchi M. Intermediate filaments of myofibroblasts. Immunochemical and immu-nocytochemical analyses. Pathol Res Pract 1987 Apr;182(2):248-254.
  45. Eyden B. Electron microscopy in the study of myofibroblastic lesions. Semin Diagn Pathol 2003 Feb;20(1):13-24.
  46. Eyden BP. Brief review of the fibronexus and its significance for myofibroblastic differentiation and tumor diagnosis. Ultrastruct Pathol 1993 Nov-Dec;17(6):611-622.
  47. Kohnen G, Kertschanska S, Demir R, Kaufmann P. Placental villous stroma as a model system for myofibroblast differen-tiation. Histochem Cell Biol 1996 Jun;105(6):415-429.
  48. Gabbiani G. The myofibroblast in wound healing and fibrocontractive diseases. J Pathol 2003 Jul;200(4):500-503.
  49. Luksic I, Suton P, Manojlovic S, Virag M, Petrovecki M, Macan D. Significance of myofibroblast appearance in squamous cell carcinoma of the oral cavity on the occurrence of occult regional metastases, distant metastases, and survival. Int J Oral Maxillofac Surg 2015 Sep;44(9):1075-1080.
  50. Guan H, Tan J, Zhang F, Gao L, Bai L, Qi D, Dong H, Zhu L, Li X, Liu T. Myofibroblasts from salivary gland adenoid cystic carcinomas promote cancer invasion by expressing MMP2 and CXCL12. Histopathology 2015 May;66(6):781-790.
  51. Jensen DH, Reibel J, Mackenzie IC, Dabelsteen E. Single cell migration in oral squamous cell carcinoma –possible evidence of epithelial-mesenchymal transition in vivo. J Oral Pathol Med 2015 Oct;44(9):674-679.
  52. Grassi G, Seravalle G, Mancia G. Sympathetic activation in cardiovascular disease: evidence, clinical impact and therapeutic implications. Eur J Clin Invest 2015 Dec;45(12):1367-1375.
  53. Cullington D, Goode KM, Zhang J, Cleland JG, Clark AL. Is heart rate important for patients with heart failure in atrial fibrillation? JACC Heart Fail 2014 Jun;2(3):213-220.
  54. Wikstrand J, HJalmarson A, Waagstein F, Fagerberg J, Goldstein S, Kjekshus J, Wedel H; MERIT-HF Study Group. Dose of metoprolol CR/XL and clinical outcomes in patients with heart failure: analysis of the experience in metoprolol CR/XL randomized intervention trial in chronic heart failure (MERIT-HF). J Am Coll Cardiol 2002 Aug;40(3):491-498.
  55. Yancy CW, Jessup M, Bozkurt B, Bulter J, Casey DE Jr, Colvin MM, Drazner MH, Filippatos GS, Fonarow GC, Givertz MM, et al. 2017 ACC/AHA/HFSA focused update of the 2013 ACCF/AHA guideline for the management of heart failure: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Failure Society of America. J Am Coll Cardiol 2017 Aug;70(6):776-803.
  56. Luetic AT. First experience in clinical application of KANET. Donald School J Ultrasound Obstet Gynecol 2015;9(1):96-99.
  57. Vasilj O. Is in utero fetal neurological assessment comparible to postnatal neurological assessment? Donald School J Ultrasound Obstet Gynecol 2015;9(1):91-95.
  58. Tomasovic S, Predojevic M. 4D ultrasound medical devices for recent advances on the etiology of cerebral palsy. Acta Inform Med 2011 Dec;19(4):228-234.
  59. Vladareanu R, Lebit D, Constantinescu S. Ultrasound assessment of fetal neurobehavior in high-risk pregnancies. Donald School J Ultrasound Obstet Gynecol 2012 Apr-Jun;6(2):132-147.
  60. Honemeyer U, Talic A, Therwat A, Paulose I, Patidar R. The clinical value of KANET test in studying fetal neurobehavior in normal and at-risk pregnancies. J Perinat Med 2013 Mar;41(2):187-197.
  61. Kadic AS. Fetal neurology: the role of fetal stress. Donald School J Ultrasound Obstet Gynecol 2015;9(1):30-39.
  62. Hata T, Kanenishi J, Hanoka U, Uematsu R, Marumo G, Tanaka H. HDlive study of fetal development and behavior. Donald School J Ultrasound Obstet Gynecol 2014;8(3):250-265.
  63. Reynoso C, Crespo-Eguílaz N, Alcázar JL, Narbona J. Motor behavior of human fetuses during the second trimester of gestation: a longitudinal ultrasound study. An Pediatr (Barc) 2015 Mar;82(3):183-191.
  64. Predojević M, Talić A, Stanojević M, Kurjak A, Salihagić Kadić A. Assessment of motoric and hemodynamic parameters in growth restricted fetuses-case study. J Matern Fetal Neonatal Med 2014 Feb;27(3):247-251.
  65. Kurjak A, Talic A, Stanojevic M, Honemeyer U, Serra B, Prats P, Di Renzo GC. The study of fetal neurobehavior in twins in all three trimesters of pregnancy. J Matern Fetal Neonatal Med 2013 Aug;26(12):1186-1195.
  66. Athanasiadis AP, Mikos T, Tambakoudis GP, Theodoridis TD, Papastergiou M, Assimakopoulos E, Tarlatzis BC. Neuro-developmental fetal assessment using Kanet scoring system in low and high-risk pregnancies. J Matern Fetal Neonatal Med 2013;26(4):363-368.
  67. Kurjak A, Stanojević M, Predojević M, Laušin I, Salihagić-Kadić A. Neurobehavior in fetal life. Semin Fetal Neonatal Med 2012 Dec;17(6):319-323.
  68. Hepper PG, Dornan JC, Lynch C, Maguire JF. Alcohol delays the emergence of the fetal elicited startle response, but only transiently. Physiol Behav 2012 Aug 20;107(1):76-81.
  69. Talic A, Kurjak A, Stanojevic M, Honemeyer U, Badreldeen A, Direnzo GC. The assessment of fetal brain function in fetuses with ventriculomegaly: the role of the Kanet test. J Matern Fetal Neonatal Med 2012 Aug;25(8):1267-1272.
  70. Kurjak A, Honemeyer U, Stanojevic M, Zalud I. Comparison between antenatal neurodevelopmental test and fetal Doppler in the assessment of fetal well-being. J Perinat Med 2013 Jan;41(1):107-114.
  71. Neto MR. KANET in Brazil: first experience. Donald School J Ultrasound Obstet Gynecol 2015;9(1):1-5.
  72. Morokuma S, Fukushima K, Yumoto Y, Uchimura M, Fujiwara A, Matsumoto M, Satoh S, Nakano H. Simplified ultrasound screening for fetal brain function based on behavioral pattern. Early Hum Dev 2007 Mar;83(3):177-181.
  73. Kurjak A, Tikvica Luetic A, Stanojevic M, Talic A, Zalud I, Al-Noobi M, Perva S, Abushama M, Tomasovic S, Zaputovic S, et al. Further experience in the clinical assessment of fetal neurobehavior. Donald School J Ultrasound Obstet Gynecol 2010 Jan-Mar;4(1):59-71.
  74. Kurjak A, Abo-Yaqoub S, Stanojevic M, Yigiter AB, Vasilj O, Lebit D, Shaddad AN, Ahmed B, Kavak ZN, Miskovic B, et al. The potential of 4D sonography in the assessment of fetal neurobehavior: multicentric study in high-risk pregnancies. J Perinat Med 2010;38(1):77-82.
  75. Miskovic B, Vasilj O, Stanojevic M, Ivankovicc D, Kerner M, Tikvica A. The comparison of fetal behavior in high-risk and normal pregnancies assessed by four-dimensional ultrasound. J Matern Fetal Neonatal Med 2010 Dec;23(12):1461-1467.
  76. Kurjak A, Ahmed B, Abo-Yaguab S, Younis M, Saleh H, Shaddad AN, Vasilj O, Al Bahar AJ, Miskovic B, Khenyab N. An attempt to introduce neurological test for fetus based on 3D and 4D sonography. Donald School J Ultrasound Obstet Gynecol 2008;2:29-44.
  77. Livingston JH, Stivaros S, Warren D, Crow YJ. Intracranial calcification in childhood: a review of aetiologies and recognizable phenotypes. Dev Med Child Neurol 2014 Jul;56(7):612-626.
  78. Couvreur J, Desmonts G, Tournier G, Szusterkac M. A homogeneous series of 210 cases of congenital toxoplasmosis in 0 to 11-month-old infants detected prospectively. Ann Pediatr (Paris) 1984 Nov;31(10):815-819. (French).
  79. Valentini P, Annunziata ML, Angelone DF, Masini L, De Santis M, Testa A, Grillo RL, Speziale D, Ranno O. Role of spiramycin/cotrimoxazole association in the mother-to-child transmission of toxoplasmosis infection in pregnancy. Eur J Clin Microbiol Infect Dis 2009 Mar;28(3):297-300.
  80. Valentini P, Buonsenso D, Barone G, Serranti D, Calzedda R, Ceccarelli M, Speziale D, Ricci R, Masini L. Spiramycin/cotrimoxazole versus pyrimethamine/sulfonamide and spiramycin alone for the treatment of toxoplasmosis in pregnancy. J Perinatol 2015 Feb;35(2):90-94.
  81. Masini L, De Santis M, Apicella M, Noia G, Santangelo R, Speziale D, Lanzone A, Valentini P. Prenatal diagnosis by ultrasound and amniocentesis in a single center cohort of 1065 pregnancies complicated by maternal Toxoplasma infection. ISUOG 2017—27th World Congress—16-19 September, Vienna, Austria OC05.05. Ultrasound Obstet Gynecol 2017;50(Suppl 1):10.
  82. Vynnycky E, Adams EJ, Cutts FT, Reef SE, Navar AM, Simons E, Yoshida LM, Brown DW, Jackson C, Strebel PM, et al. Using seroprevalence and immunisation coverage data to estimate the global burden of congenital rubella syndrome, 1996-2010: a systematic review. PLoS One 2016 Mar 10;11(3):e0149160.
  83. Duszak RS. Congenital rubella syndrome—major review. Optometry 2009 Jan;80(1):36-43.
  84. Hutton J. Does rubella Cause autism: a 2015 reappraisal? Front Hum Neurosci 2016 Feb 1;10:25.
  85. Thompson KM, Simons EA, Badizadegan K, Reef SE, Cooper LZ. Characterization of the risks of adverse outcomes following rubella infection in pregnancy. Risk Anal 2016 Jul;36(7):1315-1331.
  86. De Santis M, Cavaliere AF, Straface G, Caruso A. Rubella infection in pregnancy. Reprod Toxicol 2006 May;21(4):390-298.
  87. Harger JH, Ernest JM, Thurnau GR, Moawad A, Thom E, Landon MB, Paul R, Miodovnik M, Dombrowski M, Sibai B, et al. Frequency of congenital varicella syndrome in a prospective cohort of 347 pregnant women. Obstet Gynecol 2002 Aug;100(2):260-265.
  88. Enders G, Miller E, Cradock-Watson J, Bolley I, Ridehalgh M. Consequences of varicella and herpes zoster in pregnancy: prospective study of 1739 cases. Lancet 1994 Jun 18;343(8912):1548-1551.
  89. Tan MP, Koren G. Chickenpox in pregnancy: revisited. Reprod Toxicol 2006 May;21(4):410-420.
  90. Pastuszak AL, Levy M, Schick B, Zuber C, Feldkamp M, Gladstone J, Bar-Levy F, Jackson E, Donnenfeld A, Meschino W, et al. Outcome after maternal varicella infection in the first 20 weeks of pregnancy. N Engl J Med 1994 Mar 31;330(13):901-905.
  91. Pretorius DH, Hayward I, Jones KL, Stamm E. Sonographic evaluation of pregnancies with maternal varicella infection. J Ultrasound Med 1992 Sep;11(9):459-463.
  92. Verstraelen H, Vanzieleghem B, Defoort P, Vanhaesebrouck P, Temmerman M. Prenatal ultrasound and magnetic resonance imaging in fetal varicella syndrome: correlation with pathology findings. Prenat Diagn 2003 Sep;23(9):705-709.
  93. Paryani SG, Arvin AM. Intrauterine infection with varicella-zoster virus after maternal varicella. N Engl J Med 1986 Jun 12;314(24):1542-1546.
  94. Meyberg-Solomayer GC, Fehm T, Muller-Hansen I, Enders G, Poets C, Wallwiener D, Solomayer EF. Prenatal ultrasound diagnosis, follow-up, and outcome of congenital varicella syndrome. Fetal Diagn Ther 2006;21(3):296-301.
  95. Pichler M, Staffler A, Bonometti N, Messner H, Deluca J, Thuile T, Kluge R, Schmuth M, Eisendle K. Premature newborns with fatal intrauterine herpes simplex virus-1 infection: first report of twins and review of the literature. J Eur Acad Dermatol Venereol 2015 Jun;29(6):1216-1220.
  96. Hutto C, Arvin A, Jacobs R, Steele R, Stagno S, Lyrene R, Willett L, Powell D, Andersen R, Werthammer J, et al. Intrauterine herpes simplex virus infections. J Pediatr 1987 Jan;110(1):97-101.
  97. Florman AL, Gershon AA, Blackett PR, Nahmias AJ. Intrauterine infection with herpes simplex virus: resultant congenital malformations. JAMA 1973 Jul 9;225(2):129-132.
  98. Plourde AR, Bloch EM. A literature review of Zika virus. Emerg Infect Dis 2016 Jul;22(7):1185-1192.
  99. Paixão ES, Barreto F, Teixeira Mda G, Costa Mda C, Rodrigues LC. History, epidemiology, and clinical manifestations of Zika: a systematic review. Am J Public Health 2016 Apr;106(4):606-612.
  100. Rasmussen SA, Jamieson DJ, Honein MA, Petersen LR. Zika virus and birth defects—reviewing the evidence for causality. N Engl J Med 2016 May 19;374(20):1981-1987.
  101. Honein MA, Dawson AL, Petersen EE, Jones AM, Lee EH, Yazdy MM, Ahmad N, Macdonald J, Evert N, Bingham A, et al. Birth defects among fetuses and infants of US women with evidence of possible Zika virus infection during pregnancy. JAMA 2017 Jan 3;317(1):59-68.
  102. Chervenak FA, Jeanty P, Cantraine F, Chitkara U, Venus I, Berkowitz RL, Hobbins JC. The diagnosis of fetal microcephaly. Am J Obstet Gynecol 1984 Jul 1;149(5):512-517.
  103. Papageorghiou AT, Thilaganathan B, Bilardo CM, Ngu A, Malinger G, Herrera M, Salomon LJ, Riley LE, Copel JA. ISUOG Interim Guidance on ultrasound for Zika virus infection in pregnancy: information for healthcare professionals. Ultrasound Obstet Gynecol 2016 Apr;47(4):530-532.
  104. Chibueze EC, Parsons AJ, Lopes KD, Yo T, Swa T, Nagata C, Horita N, Morisaki N, Balogun OO, Dagvadorj A, et al. Diagnostic accuracy of ultrasound scanning for prenatal microcephaly in the context of Zika virus infection: a systematic review and meta-analysis. Sci Rep 2017 May 23;7(1):2310.
  105. Cordeiro MT. Zika virus: laboratory diagnosis. In: Zika in focus. Springer International Publishing; 2017. pp. 59-62.
  106. Mlakar J, Korva M, Tul N, Popović M, Poljšak-Prijatelj M, Mraz J, Kolenc M, Resman Rus K, Vesnaver Vipotnik T, Fabjan Vodušek V, et al. Zika virus associated with microcephaly. N Engl J Med 2016 Mar 10;374(10):951-958.
  107. Zare Mehrjardi M, Keshavarz E, Poretti A, Hazin AN. Neuroimaging findings of Zika virus infection: a review article. Jpn J Radiol 2016 Dec;34(12):765-770.
  108. Oliveira Melo AS, Malinger G, Ximenes R, Szejnfeld PO, Alves Sampaio S, Bispo de Filippis AM. Zika virus intrauterine infection causes fetal brain abnormality and microcephaly: tip of the iceberg? Ultrasound Obstet Gynecol 2016 Jan;47(1):6-7.
  109. Araujo AQ, Silva MT, Araujo AP. Zika virus-associated neurological disorders: a review. Brain 2016;139(8):2122-2130.
  110. Brasil P, Pereira JP Jr, Moreira ME, Ribeiro Nogueira RM, Damasceno L, Wakimoto M, Rabello RS, Valderramos SG, Halai UA, Salles TS, et al. Zika virus infection in pregnant women in Rio de Janeiro. N Engl J Med 2016 Dec 15;375(24):2321-2334.
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