International Journal of Clinical Pediatric Dentistry

Register      Login

VOLUME 16 , ISSUE 6 ( November-December, 2023 ) > List of Articles


To Evaluate the Success of Natural Compound: Curcumin as Obturating Material in Primary Teeth

Rashmi Dalal, Anil Gupta, Ankit Srivastava, Shalini Garg, Vishal Sharma, Vijay Sharma

Keywords : Curcumin, Obturation, Primary teeth, Pulpectomy

Citation Information : Dalal R, Gupta A, Srivastava A, Garg S, Sharma V, Sharma V. To Evaluate the Success of Natural Compound: Curcumin as Obturating Material in Primary Teeth. Int J Clin Pediatr Dent 2023; 16 (6):793-799.

DOI: 10.5005/jp-journals-10005-2485

License: CC BY-NC 4.0

Published Online: 01-02-2024

Copyright Statement:  Copyright © 2023; The Author(s).


Background: In a quest a search for newer obturating materials, trends have now shifted from more harmful chemical-based compounds to less toxic and more natural Ayurvedic or herbal materials. Curcumin—a natural extract from turmeric rhizomes, possesses anti-inflammatory and antimicrobial properties and thus may be used as a novel obturating material in the primary teeth. Objective: To evaluate and compare the efficacy of curcumin powder mixed with zinc oxide-eugenol (ZOE) and ZOE as obturating materials in primary molars. Materials and methods: A total of 30 primary molars indicated for pulpectomy were selected from 4–8-year-old children and divided into two groups. Group 1—ZOE group included 11 teeth, and in group II, 19 teeth were obturated with—curcumin mixed with ZOE mixed (ZOE + C). The efficacy of these obturation materials was evaluated both clinically and radiographically after 3, 6, and 9 months. Results: At 9 months, there was a significant reduction in preoperative clinical signs and symptoms. Mobility was absent in all the teeth in group I, while 5 teeth presented with mobility in group II after 9 months. On radiographic assessment, at the end of the 9 months, material resorption was similar to physiological root resorption in 40% of teeth in group I and 22.2% in group II. Interradicular radiolucency increased in 66.7% of teeth in group II when compared to 20% of teeth in group I. Pathological root resorption was seen in 10% of roots in the ZOE group and 55.6% of the roots in the ZOE+C group. Conclusion: Despite the well-documented antibacterial and anti-inflammatory properties of curcumin powder in literature, considering the results of the present study, we cannot suggest curcumin powder as successful alternative obturation material for treating deciduous teeth.

  1. Miglani S. Burden of dental caries in India: current scenario and future strategies. Int J Clin Pediatr Dent 2020;13(2):155–159. DOI: 10.5005/jp-journals-10005-1733
  2. Collado V, Pichot H, Delfosse C, et al. Impact of early childhood caries and its treatment under general anesthesia on orofacial function and quality of life: a prospective comparative study. Med Oral Patol Oral Cir Bucal 2017;22(3):333–341. DOI: 10.4317/medoral.21611
  3. Setia V, Pandit IK, Srivastava N, et al. Space maintainers in dentistry: past to present. J Clin Diagn Res 2013;7(10):2402–2405. DOI: 10.7860/JCDR/2013/6604.3539
  4. Management of the developing dentition and occlusion in pediatric dentistry. Pediatr Dent 2017;39(6):334–347.
  5. Chonat A, Rajamani T, Ephraim R. Obturating materials in primary teeth—a review, research and reviews. J Dent Sci 2018;6(1):20–25.
  6. Barja-Fidalgo F, Moutinho-Ribeiro M, Oliveira MA, et al. A systematic review of root canal filling materials for deciduous teeth: is there an alternative for zinc oxide-eugenol. ISRN Dent 2011:367318. DOI: 10.5402/2011/367318
  7. Gupta B, Singh I, Goyal P, et al. A clinical and radiographic study of four different root canal filling materials in primary molars—an in vivo study. Dent J Adv Stud 2019;7(2):061–065. DOI: 10.1055/s-0039-1692611
  8. Agarwal S, Gupta S, Tandon S, et al. Comparative evaluation of ocimum sanctum and calcium hydroxide mix as an obturating material in deciduous molars: an in vivo study. Int J Clin Pediatr Dent 2020;13(6):617–621. DOI: 10.5005/jp-journals-10005-1840
  9. Khairwa A, Bhat M, Sharma R, et al. Clinical and radiographic evaluation of zinc oxide with aloe vera as an obturating material in pulpectomy: an in vivo study. J Indian Soc Pedod Prev Dent 2014;32(1):33–38. DOI: 10.4103/0970-4388.127051
  10. Kocaadam B, Şanlier N. Curcumin, an active component of turmeric (Curcuma longa), and its effects on health. Crit Rev Food Sci Nutr 2017;57(13):2889-2895. DOI: 10.1080/10408398.2015.1077195
  11. Nagpal M, Sood S. Role of curcumin in systemic and oral health: an overview. J Nat Sci Biol Med 2013;4(1):3–7. DOI: 10.4103/0976-9668.107253
  12. Forouzanfar F, Forouzanfar A, Sathyapalan T, et al. Curcumin for the management of periodontal diseases: a review. Curr Pharm Des 2020;26(34):4277–4284. DOI: 10.2174/1381612826666200513112607
  13. Kuwatada JS, Raja M, Sood P. Turmeric: a boon to oral health. Int J Oral Care Res 2017;5(4):338–341. DOI: 10.5005/jp-journals-10051-0128
  14. Purohit RN, Bhatt M, Purohit K, et al. Clinical and radiological evaluation of turmeric powder as a pulpotomy medicament in primary teeth: an in vivo study. Int J Clin Pediatr Dent 2017;10(1):37–40. DOI: 10.5005/jp-journals-10005-1404
  15. Menni AC, Ambati NR, Prasad MG. Clinical and radiographic evaluation of Curcumin Gel mixed Endoflas (CGE) powder as obturating material in primary molars. Braz Dent Sci 2020;23(1):1–8. DOI: 10.14295/bds.2020.v23i1.1733
  16. Pandranki J, V Vanga NR, Chandrabhatla SK. Zinc oxide eugenol and Endoflas pulpectomy in primary molars: 24-month clinical and radiographic evaluation. J Indian Soc Pedod Prev Dent 2018;36(2):173–180. DOI: 10.4103/JISPPD.JISPPD_1179_17
  17. Chen X, Liu X, Zhong J. Clinical and radiographic evaluation of pulpectomy in primary teeth: a 18-months clinical randomized controlled trial. Head Face Med 2017;13(1):12. DOI: 10.1186/s13005-017-0145-1
  18. Gould JM. Root canal therapy for infected primary molar teeth–preliminary report. ASDC J Dent Child 1972;39(4):269–273.
  19. Fuks AB, Eidelman E, Pauker N. Root fillings with Endoflas in primary teeth: a retrospective study. J Clin Pediatr Dent 2002;27(1):41–45. DOI: 10.17796/jcpd.27.1.pp237453707386m1
  20. Allen KR. Endodontic treatment of primary teeth. Aust Dent J 1979;24(5):347–351. DOI: 10.1111/j.1834-7819.1979.tb05807.x
  21. Coll JA, Josell S, Casper JS. Evaluation of a one-appointment formocresol pulpectomy technique for primary molars. Pediatr Dent 1985;7(2):123–129.
  22. Barker BC, Lockett BC. Endodontic experiments with resorbable paste. Aust Dent J 1971;16(6):364–372. DOI: 10.1111/j.1834-7819.1971.tb03433.x
  23. Spedding RH. Root canal treatments for primary teeth. Dent Clin North Am 1973;17(1):105–124.
  24. Mortazavi M, Mesbahi M. Comparison of zinc oxide and eugenol, and Vitapex for root canal treatment of necrotic primary teeth. Int J Paediatr Dent. 2004;14(6):417–424. DOI: 10.1111/j.1365-263X.2004.00544.x
  25. Chainani-Wu N. Safety and anti-inflammatory activity of curcumin: a component of tumeric (Curcuma longa). J Altern Complement Med 2003;9(1):161–168. DOI: 10.1089/107555303321223035
  26. Priyadarsini KI, Maity DK, Naik GH, et al. Role of phenolic O-H and methylene hydrogen on the free radical reactions and antioxidant activity of curcumin. Free Radic Biol Med 2003;35(5):475–484. DOI: 10.1016/s0891-5849(03)00325-3
  27. Menon VP, Sudheer AR. Antioxidant and anti-inflammatory properties of curcumin. Adv Exp Med Biol 2007;595:105–125. DOI: 10.1007/978-0-387-46401-5_3
  28. Aggarwal BB, Harikumar KB. Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. Int J Biochem Cell Biol 2009;41(1):40–59. DOI: 10.1016/j.biocel.2008.06.010
  29. Devaraj S, Jagannathan N, Neelakantan P. Antibiofilm efficacy of photoactivated curcumin, triple and double antibiotic paste, 2% chlorhexidine and calcium hydroxide against Enterococcus fecalis in vitro. Sci Rep 2016;6:24797. DOI: 10.1038/srep24797
  30. Joy Sinha D, D S Nandha K, Jaiswal N, et al. Antibacterial effect of Azadirachta indica (neem) or Curcuma longa (turmeric) against Enterococcus faecalis compared with that of 5% sodium hypochlorite or 2% chlorhexidine in vitro. Bull Tokyo Dent Coll 2017;58(2):103–109. DOI: 10.2209/tdcpublication.2015-0029
  31. Yadav RK, Tikku AP, Chandra A, et al. A comparative evaluation of the antimicrobial efficacy of calcium hydroxide, chlorhexidine gel, and a curcumin-based formulation against Enterococcus faecalis. Natl J Maxillofac Surg 2018;9(1):52–55. DOI: 10.4103/njms.NJMS_47_17
  32. Neelakantan P, Subbarao C, Sharma S, et al. Effectiveness of curcumin against Enterococcus faecalis biofilm. Acta Odontol Scand 2013;71(6):1453–1457. DOI: 10.3109/00016357.2013.769627
  33. Reddy AR, Dinesh P, Prabhakar AS, et al. A comprehensive review on SAR of curcumin. Mini Rev Med Chem 2013;13(12):1769–1777. DOI: 10.2174/1389557511313120007
  34. Mandroli PS, Bhat K. An in-vitro evaluation of antibacterial activity of curcumin against common endodontic bacteria. J Appl Pharm Sci 2013;3(10):106–108. DOI: 10.7324/JAPS.2013.31018
  35. Hugar SM, Kukreja P, Hugar SS, et al. Comparative evaluation of clinical and radiographic success of formocresol, propolis, turmeric gel, and calcium hydroxide on pulpotomized primary molars: A preliminary study. Int J Clin Pediatr Dent 2017;10(1):18–23. DOI: 10.5005/jp-journals-10005-1400
  36. Prabhakar AR, Mandroli PS, Bhat K. Pulpotomy with curcumin: Histological comparison with mineral trioxide aggregate in rats. Indian J Dent Res 2019;30(1):31–36. DOI: 10.4103/ijdr.IJDR_278_17
  37. Radhakrishna AN, Menni ACA, Prasad MGH, et al. The success rate of Endoflas powder mixed with Curcumin gel as obturating material in primary molars: case- series. JBPR 2017;6(2):100–106.
  38. Jäger R, Lowery RP, Calvanese AV, et al. Comparative absorption of curcumin formulations. Nutr J 2014;13:11. DOI: 10.1186/1475-2891-13-11
  39. Karthikeyan A, Senthil N, Min T. Nanocurcumin: a promising candidate for therapeutic applications. Front Pharmacol 2020;11:487. DOI: 10.3389/fphar.2020.00487
  40. Gorabi AM, Kiaie N, Hajighasemi S, et al. The effect of curcumin on the differentiation of mesenchymal stem cells into mesodermal lineage. Molecules 2019;24(22):4029. DOI: 10.3390/molecules24224029
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.