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VOLUME 16 , ISSUE 5 ( September-October, 2023 ) > List of Articles

ORIGINAL RESEARCH

Arginine: A New Paradigm in Preventive Oral Care

Varinder Goyal, Satyawan Damle, Manjunath P Puranik, Sivakumar Nuvvula, Madhu Kakanur, Baranya S Suprabha, Prathima Sreenivasan, Umesh Wadgave, S Shyam, Dewakshi Thakur

Keywords : Arginine, Dental caries, Fluoride

Citation Information : Goyal V, Damle S, Puranik MP, Nuvvula S, Kakanur M, Suprabha BS, Sreenivasan P, Wadgave U, Shyam S, Thakur D. Arginine: A New Paradigm in Preventive Oral Care. Int J Clin Pediatr Dent 2023; 16 (5):698-706.

DOI: 10.5005/jp-journals-10005-2693

License: CC BY-NC 4.0

Published Online: 10-11-2023

Copyright Statement:  Copyright © 2023; The Author(s).


Abstract

Dental caries is ubiquitous and one of the most prevalent oral diseases and the foremost cause of dental pain and poor quality of life (QoL). Fluoride is an effective caries preventive agent; however, despite its use, there remain some gaps in prevention of dental caries. Arginine, an amino acid, helps to maintain a noncariogenic plaque. It shows synergistic effects with fluoride in dental caries and can help nourish the tooth by enhancing the remineralization effect of fluoride. Supplementing fluoride dentifrices with arginine can bridge the gap in caries prevention. Several clinical studies with 1.5% arginine + fluoride provide evidence for its use in prevention of dental caries. This report throws light on the benefits of arginine in dental caries and guides on its use with fluoride. Recommendations given in the report will help in effective prevention of dental caries.

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  1. Elsadek YE, Baker SR. Oral health promotion through health-promoting schools in developing countries: a scoping review. Community Dent Oral Epidemiol 2023;51(6):1197–1208. DOI: 10.1111/cdoe.12864
  2. Miglani S. Burden of dental caries in India: current scenario and future strategies. Int J Clin Pediatr Dent 2020;13(2):155–159. DOI: 10.5005/jp-journals-10005-1733
  3. Pandey P, Nandkeoliar T, Tikku AP, et al. Prevalence of dental caries in the indian population: a systematic review and meta-analysis. J Int Soc Prev Community Dent 2021;11(3):256–265. DOI: 10.4103/jispcd.JISPCD_42_21
  4. Kassebaum NJ, Smith AGC, Bernabé E, et al. Global, regional, and national prevalence, incidence, and disability-adjusted life years for oral conditions for 195 countries, 1990-2015: a systematic analysis for the global burden of diseases, injuries, and risk factors. J Dent Res 2017;96(4):380–387. DOI: 10.1177/0022034517693566
  5. Berezovsky B, Bencko V. Oral health in a context of public health: prevention-related issue. Cent Eur J Public Health 2021;29(4):317–321. DOI: 10.21101/cejph.a6940
  6. Cummins D. The development and validation of a new technology, based upon 1.5% arginine, an insoluble calcium compound and fluoride, for everyday use in the prevention and treatment of dental caries. J Dent 2013;41(Suppl 2):S1–S11. DOI: 10.1016/j.jdent.2010.04.002
  7. Featherstone JD. The caries balance: contributing factors and early detection. J Calif Dent Assoc 2003;31(2):129–133.
  8. Pitts NB, Zero DT, Marsh PD, et al. Dental caries. Nat Rev Dis Primers 2017;3:17030. DOI: 10.1038/nrdp.2017.30
  9. KonagalaRK, MandavaJ, AnwarullahA, et al. Synergistic effect of arginine on remineralization potential of fluoride varnish and nanohydroxyapatite on artificial caries lesions: an in vitro study. J Contemp Dent Pract 2020;21(9):1048–1053.
  10. Bijle MNA, Ekambaram M, Lo EC, et al. The combined enamel remineralization potential of arginine and fluoride toothpaste. J Dent 2018;76:75–82. DOI: 10.1016/j.jdent.2018.06.009
  11. Souza ML, Cury JA, Tenuta LM, et al. Comparing the efficacy of a dentifrice containing 1.5% arginine and 1450 ppm fluoride to a dentifrice containing 1450 ppm fluoride alone in the management of primary root caries. J Dent 2013;41(Suppl 2):S35–S41. DOI: 10.1016/j.jdent.2010.04.006
  12. Ahsan H. Potential benefits of arginine formulation in oral health care products. Oral Sci Int 2019;16(3):130. DOI: 10.1002/osi2.1021
  13. González-Cabezas C, Fernández CE. Recent advances in remineralization therapies for caries lesions. Adv Dent Res 2018;29(1):55–59. DOI: 10.1177/0022034517740124
  14. Lagerweij MD, van LoverenC. Declining caries trends: are we satisfied? Curr Oral Health Rep 2015;2(4):212–217. DOI: 10.1007/s40496-015-0064-9
  15. Selwitz RH, Ismail AI, Pitts NB. Dental caries. Lancet 2007;369(9555): 51–59. DOI: 10.1016/S0140-6736(07)60031-2
  16. Birch S, Bridgman C, Brocklehurst P, et al. Prevention in practice–a summary. BMC Oral Health 2015;15(Suppl 1):S12. DOI: 10.1186/1472-6831-15-S1-S12
  17. Liu YL, Nascimento M, Burne R, et al. Progress toward understanding the contribution of alkali generation in dental biofilms to inhibition of dental caries. Int J Oral Sci 2012;4(3):135–140. DOI: 10.1038/ijos.2012.54
  18. Burne RA, Marquis RE. Alkali production by oral bacteria and protection against dental caries. FEMS Microbiol Lett 2000;193(1):1–6. DOI: 10.1111/j.1574-6968.2000.tb09393.x
  19. Nascimento MM, Gordan VV, Garvan CW, et al. Correlations of oral bacterial arginine and urea catabolism with caries experience. Oral Microbiol Immunol 2009;24(2):89–95. DOI: 10.1111/j.1399-302X.2008.00477.x
  20. Gordan VV, Garvan CW, Ottenga ME, et al. Could alkali production be considered an approach for caries control? Caries Res 2010;44(6): 547–554. DOI: 10.1159/000321139
  21. Van N, Carr J, Derrick L, et al. The oral and systemic healthbenefits of arginine. Dimens Dent Hyg 2019;17(10):40–43.
  22. Srisilapanan P, Korwanich N, Yin W, et al. Comparison of the efficacy of a dentifrice containing 1.5% arginine and 1450 ppm fluoride to a dentifrice containing 1450 ppm fluoride alone in the management of early coronal caries as assessed using quantitative light-induced fluorescence. J Dent 2013;41(Suppl 2):S29–S34. DOI: 10.1016/j.jdent.2010.04.005
  23. Nascimento MM, Alvarez AJ, Huang X, et al. Metabolic profile of supragingival plaque exposed to arginine and fluoride. J Dent Res 2019;98(11):1245–1252. DOI: 10.1177/0022034519869906
  24. Bijle MN, Ekambaram M, Lo E, et al. Physicochemical characteristics of arginine enriched NaF varnish: an in vitro study. Polymers 2020;12(12):2998. DOI: 10.3390/polym12122998
  25. Carda-Diéguez M, Moazzez R, Mira A. Functional changes in the oral microbiome after use of fluoride and arginine containing dentifrices: a metagenomic and metatranscriptomic study. Microbiome 2022;10(1):159. DOI: 10.1186/s40168-022-01338-4
  26. Cheng X, Xu P, Zhou X, et al. Arginine promotes fluoride uptake into artificial carious lesions in vitro. Aust Dent J 2015;60(1):104–111. DOI: 10.1111/adj.12278
  27. Yin W, Hu DY, Li X, et al. The anti-caries efficacy of a dentifrice containing 1.5% arginine and 1450 ppm fluoride as sodium monofluorophosphate assessed using Quantitative Light-induced Fluorescence (QLF). J Dent 2013;41(Suppl 2):S22–S28. DOI: 10.1016/j.jdent.2010.04.004
  28. Li X, Zhong Y, Jiang X, et al. Randomized clinical trial of the efficacy of dentifrices containing 1.5% arginine, an insoluble calcium compound and 1450 ppm fluoride over two years. J Clin Dent 2015;26(1):7–12.
  29. Petersen PE, Hunsrisakhun J, Thearmontree A, et al. School-based intervention for improving the oral health of children in southern Thailand. Community Dent Health 2015;32(1):44–50.
  30. Kraivaphan P, Amornchat C, Triratana T, et al. Two-year caries clinical study of the efficacy of novel dentifrices containing 1.5% arginine, an insoluble calcium compound and 1,450 ppm fluoride. Caries Res 2013;47(6):582–590. DOI: 10.1159/000353183
  31. Acevedo AM, Montero M, Rojas-Sanchez F, et al. Clinical evaluation of the ability of CaviStat in a mint confection to inhibit the development of dental caries in children. J Clin Dent 2008;19:1-8.
  32. Nascimento MM, Liu Y, Kalra R, et al. Oral arginine metabolism may decrease the risk for dental caries in children. J Dent Res 2013;92(7):604–608. DOI: 10.1177/0022034513487907
  33. Cantore R, Petrou I, Lavender S, et al. In situ clinical effects of new dentifrices containing 1.5% arginine and fluoride on enamel de- and remineralization and plaque metabolism. J Clin Dent 2013;24 Spec no A:A32–A44.
  34. Hu DY, Yin W, Li X, et al. A clinical investigation of the efficacy of a dentifrice containing 1.5% arginine and 1450 ppm fluoride, as sodium monofluorophosphate in a calcium base, on primary root caries. J Clin Dent 2013;24 Spec no A:A23–A31.
  35. Ástvaldsdóttir A, Naimi-Akbar A, Davidson T, et al. Arginine and caries prevention: a systematic review. Caries Res 2016;50(4):383–393. DOI: 10.1159/000446249
  36. Li J, Huang Z, Mei L, et al. Anti-caries effect of arginine-containing formulations in vivo: a systematic review and meta-analysis. Caries Res 2015;49(6):606–617. DOI: 10.1159/000435894
  37. Bijle MN, Ekambaram M, Yiu CKY. A scoping review on arginine in caries prevention. J Evid Based Dent Pract 2020;20(3):101470. DOI: 10.1016/j.jebdp.2020.101470
  38. Cummins D. Dentin hypersensitivity: from diagnosis to a breakthrough therapy for everyday sensitivity relief. J Clin Dent 2009;20(1):1–9.
  39. Singh S. Pro-Argin: a breakthrough technology for dentin hypersensitivity treatment. Int J Sci Study 2013;1(3):133–137.
  40. Fambrini E, Miceli M, Pasini M, et al. Clinical evaluation of the use of desensitizing agents in the management of dentinal hypersensitivity. Appl Sci 2022;12(21):11238. DOI: 10.3390/app122111238
  41. Panagakos F, Schiff T, Guignon A. Dentin hypersensitivity: effective treatment with an in-office desensitizing paste containing 8% arginine and calcium carbonate. Am J Dent 2009;22 Spec No A:3A–7A.
  42. Hirsiger C, Schmidlin PR, Michaelis M, et al. Efficacy of 8% arginine on dentin hypersensitivity: A multicenter clinical trial in 273 patients over 24 weeks. J Dent 2019;83:1–6. DOI: 10.1016/j.jdent.2019.01.002
  43. Schiff T, Delgado E, Zhang YP, et al. Clinical evaluation of the efficacy of an in-office desensitizing paste containing 8% arginine and calcium carbonate in providing instant and lasting relief of dentin hypersensitivity. Am J Dent 2009;22 Spec No A:8A–15A.
  44. Que K, Fu Y, Lin L, et al. Dentin hypersensitivity reduction of a new toothpaste containing 8.0% arginine and 1450 ppm fluoride: an 8-week clinical study on Chinese adults. Am J Dent 2010;23 Spec No A:28A–35A.
  45. Docimo R, Montesani L, Maturo P, et al. Comparing the efficacy in reducing dentin hypersensitivity of a new toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride to a commercial sensitive toothpaste containing 2% potassium ion: an eight-week clinical study in Rome, Italy. J Clin Dent 2009;20(1):17–22.
  46. Hsu HC, Lee SS, Chang YC. Clinical efficacy of toothpaste containing 8.0% arginine and calcium carbonate for teeth hypersensitivity. J Dent Sci 2013;8(4):444–447. DOI: 10.1016/j.jds.2013.06.008
  47. Elias Boneta AR, Ramirez K, Naboa J, et al. Efficacy in reducing dentine hypersensitivity of a regimen using a toothpaste containing 8% arginine and calcium carbonate, a mouthwash containing 0.8% arginine, pyrophosphate and PVM/MA copolymer and a toothbrush compared to potassium and negative control regimens: an eight-week randomized clinical trial. J Dent 2013;41(Suppl 1):S42–S49. DOI: 10.1016/j.jdent.2012.11.011
  48. Michaelis M, Hirsiger C, Roux D, et al. Impact of Pro-Argin on the oral health-related quality of life: a 24-week randomized, parallel-group, multicenter study. Appl Sci 2022;12(9):4431. DOI: 10.3390/app12094431
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