Comparative Evaluation of the Regenerative Potential of Blood Clot and Platelet-rich Fibrin in Young Permanent Teeth Based on the Revised American Academy of Endodontics Clinical Considerations for Regenerative Procedure: 2016
Aarathi J Prakash, Saraswathi V Naik, Prabhakar Attiguppe
Advanced platelet-rich fibrin, American Academy of Endodontics regenerative protocol 2016, Blood clot, Necrotic young permanent teeth, Stem cells of apical papilla
Aim: To compare and evaluate the regenerative potential of blood clots and platelet-rich fibrin (PRF) in IYNPT based on the revised American Academy of Endodontics (AAE) clinical considerations for regenerative endodontics 2016.
Materials and methods: A total of 20 patients (7–12 years) with immature young necrotic permanent teeth were included and irrigation and disinfection were done using the revised AAE protocol. Teeth were randomly categorized into PRF scaffolding and conventional bleeding technique. The cases were followed up for 1, 3, and 6 months for clinical and radiographic evaluation.
Result: At 6 months there was no significant difference between the groups in terms of clinical healing and periapical healing. A significant statistical difference was noted at the end of 6 months with respect to apical closure within the PRF group. A significant difference was seen in the increase in dentin thickness between groups with PRF showing more increase.
Conclusion: The PRF scaffold can be used as it induces the regenerative potential of stem cells at the apex.
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