International Journal of Clinical Pediatric Dentistry

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VOLUME 16 , ISSUE 2 ( March-April, 2023 ) > List of Articles

CASE REPORT

Expansive Oral Giant Cell Granuloma in a Pediatric Patient

Pau Cahuana-Bartra, Lluís Brunet-Llobet, Mariona Suñol-Capella, Jaume Miranda-Rius

Keywords : Giant cell lesions, Gingival tumor, Hyperplastic reactive lesion, Peripheral oral giant cell granuloma

Citation Information : Cahuana-Bartra P, Brunet-Llobet L, Suñol-Capella M, Miranda-Rius J. Expansive Oral Giant Cell Granuloma in a Pediatric Patient. Int J Clin Pediatr Dent 2023; 16 (2):405-408.

DOI: 10.5005/jp-journals-10005-2572

License: CC BY-NC 4.0

Published Online: 12-05-2023

Copyright Statement:  Copyright © 2023; The Author(s).


Abstract

Aim: This article describes a peripheral oral giant cell granuloma (POGCG) in a pediatric patient and its surgical management and histological characteristics. Background: Peripheral oral giant cell granuloma (POGCG) is a hyperplastic reactive lesion formed by a proliferation of mononuclear cells and osteoclast-type giant cells in vascular tissue, occasionally with bone formation. Generally found in women and adults, POGCG has rarely been described in children. Case description: An 8-year-old girl was consulted for an exophytic lesion in the anterior area of the upper jaw, which had increased in volume in the preceding weeks. An excisional biopsy of the tumor was performed with an electrosurgical pencil. The pathological diagnosis was POGCG. Conclusion: Excision followed by additional therapy, such as scaling and curettage, should be the first option in the treatment of POGCG. Clinical significance: Early detection of these lesions involving the periodontium is important in order to reduce bone loss and avoid pathological dental migration.


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  1. Brunet L, Miranda J, Farré M, et al. Gingival enlargement induced by drugs. Drug Saf 1996;15(3):219–231. DOI: 10.2165/00002018-199615030-00007
  2. Miranda-Rius J, Brunet-Llobet L, Lahor-Soler E, et al. Gingival enlargement induced by dihydropyridine calcium channel blockers in a young child. BMJ Case Rep 2014;2014:bcr2014206761. DOI: 10.1136/bcr-2014-206761
  3. Flaitz CM. Peripheral giant cell granuloma: a potentially aggressive lesion in children. Pediatr Dent 2000;22(3):232–233.
  4. Chaparro-Avendaño AV, Berini-Aytés L, Gay Escoda C, et al. Granuloma periférico de células gigantes. A propósito de 5 casos y revisión de la literatura. Med Oral Patol Oral Cir Buccal 2005;10(1):48–57.
  5. Pandolfi PJ, Felefli S, Flaitz CM, et al. An aggressive peripheral giant cell granuloma in a child. J Clin Pediatr Dent 1999;23(4):353–355.
  6. Motamedi MH, Eshghyar N, Jafari SM, et al. Peripheral and central giant cell granulomas of the jaws: a demographic study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007;103(6):e39–e43. DOI: 10.1016/j.tripleo.2006.12.022
  7. Chrcanovic BR, Gomes CC, Gomez RS, et al. Peripheral giant cell granuloma: an updated analysis of 2824 cases reported in the literature. J Oral Pathol Med 2018;47(5):454–459. DOI: 10.1111/jop.12706
  8. Katsikeris N, Kakarantza-Angelopoulou E, Angelopoulos AP, et al. Peripheral giant cell granuloma. Clinicopathologic study of 224 new cases and review of 956 reported cases. Int J Oral Maxillofac Surg 1988;17(2):94–99. DOI: 10.1016/s0901-5027(88)80158-9
  9. Jaffe HL. Giant cell reparative granuloma, traumatic bone cyst, and fibrous (fibro-oseous) dysplasia of the jawbones. Oral Surg Oral Med Oral Pathol 1953;6(1):159–175. DOI: 10.1016/0030-4220(53)90151-0
  10. Bodner L, Peist M, Gatot A, et al. Growth potential of peripheral giant cell granuloma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1997;83(5):548–551. DOI: 10.1016/s1079-2104(97)90118-9
  11. Grand E, Burgener E, Samson J, et al. Post-traumatic development of a peripheral giant cell granuloma in a child. Dent Traumatol 2008;24(1):124–126. DOI: 10.1111/j.1600-9657.2006.00504.x
  12. Nekouei A, Eshghi A, Jafarnejadi P, et al. A review and report of peripheral giant cell granuloma in a 4-year-old child. Case Rep Dent 2016;2016:7536304. DOI: 10.1155/2016/7536304
  13. Volpato LE, Leite CA, Anhesini BH, et al. Peripheral giant cell granuloma in a child associated with ectopic eruption and traumatic habit with control of four years. Case Rep Dent 2016;2016:6725913. DOI: 10.1155/2016/6725913
  14. Shadman N, Ebrahimi SF, Jafari S, et al. Peripheral giant cell granuloma: a review of 123 cases. Dent Res J (Isfahan) 2009;6(1):47–50.
  15. Shields JA. Peripheral giant cell granuloma: a review. J Ir Dent Assoc 1994;40(2):39–41.
  16. Wolfson L, Tal H, Covo S, et al. Peripheral giant cell granuloma during orthodontic treatment. Am J Orthod Dentofacial Orthop 1989;96(6):519–523. DOI: 10.1016/0889-5406(89)90120-0
  17. Duarte Ruiz B, Riba García Fde A, Navarro Cuéllar C, et al. Reparative giant cell granuloma in a pediatric patient. Med Oral Patol Oral Cir Bucal 2007;12(4):E331–E335.
  18. Wang C, Song Y, Peng B, et al. Expression of c-Src and comparison of cytologic features in cherubism, central giant cell granuloma and giant cell tumors. Oncol Rep 2006;15(3):589–594.
  19. Adlakha VK, Chandna P, Rehani U, et al. Peripheral giant cell granuloma. J Indian Soc Pedod Prev Dent 2010;28(4):293–296. DOI: 10.4103/0970-4388.76161
  20. Telfah H, Abdel Latif AM. Oral granulomas at Prince Rashid Hospital North Jordan. A retrospective study of 62 cases. JRMS 2006;13(2):41–45.
  21. Dimitrakopoulos I, Lazaridis N, Sakellariou P, et al. Giant cell granuloma in the temporal bone: a case report and review of the literature. J Oral Maxillofac Surg 2006;64(3):531–536. DOI: 10.1016/j.joms.2005.11.006
  22. daSilva FC, Piazzetta CM, Torres-Pereira CC, et al. Gingival proliferative lesions in children and adolescents in Brazil: a 15-year-period cross-sectional study. J Indian Soc Periodontol 2016;20(1):63–66. DOI: 10.4103/0972-124X.168493
  23. Neville BW, Damm DD, Allen CM, et al. Oral and maxillofacial pathology. 4th ed. Philadelphia (PA): Saunders; 2002. pp. 705–740.
  24. Kamal R, Dahiya P, Puri A, et al. Oral pyogenic granuloma: various concepts of etiopathogenesis. J Oral Maxillofac Pathol 2012;16(1):79–82. DOI: 10.4103/0973-029X.92978
  25. Brunet-Llobet L, Miranda-Rius J, Lahor-Soler E, et al. A Gray-purple mass on the floor of the mouth: gigantic mucogingival pyogenic granuloma in a teenage patient. Open Dent J 2014;8:125–128. DOI: 10.2174/1874210601408010125
  26. Hanemann JA, Pereira AA, Ribeiro Júnior NV, et al. Peripheral ossifying fibroma in a child: report of case. J Clin Pediatr Dent 2003;27(3):283–285.
  27. Zhang W, Chen Y, An Z, et al. Reactive gingival lesions: a retrospective study of 2,439 cases. Quintessence Int 2007;38(2):103–110.
  28. Mighell AJ, Robinson PA, Hume WJ, et al. Peripheral giant cell granuloma: a clinical study of 77 cases from 62 patients, and literature review. Oral Dis 1995;1(1):12–19. DOI: 10.1111/j.1601-0825.1995.tb00151.x
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