International Journal of Clinical Pediatric Dentistry

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VOLUME 15 , ISSUE 3 ( May-June, 2022 ) > List of Articles

RESEARCH ARTICLE

Comparative Evaluation of Salivary Fluoride Concentration after Topical Application of Silver Diamine Fluoride and Sodium Fluoride: A Randomized Controlled Trial

Zohra Jabin, Iffat Nasim, V Vishnu Priya, Nidhi Agarwal

Keywords : Enamel demineralization, Primary teeth, Saliva, Silver diamine fluoride

Citation Information : Jabin Z, Nasim I, Priya VV, Agarwal N. Comparative Evaluation of Salivary Fluoride Concentration after Topical Application of Silver Diamine Fluoride and Sodium Fluoride: A Randomized Controlled Trial. Int J Clin Pediatr Dent 2022; 15 (3):371-375.

DOI: 10.5005/jp-journals-10005-2398

License: CC BY-NC 4.0

Published Online: 30-06-2022

Copyright Statement:  Copyright © 2022; The Author(s).


Abstract

Background: The topical fluoride acts on the tooth in many ways and their most important action is inhibition of demineralization and enhancement of enamel remineralization. Aim: The purpose of this clinical trial was to assess the fluoride concentration in saliva before and after 38% silver diamine fluoride (SDF) and 5% sodium fluoride (NaF) application on enamel and duration of its availability at different time intervals. Methodology: A randomized clinical trial was conducted among 40 healthy children aged between 6 and 12 years. The participants were then randomly allocated into two different groups in which the first group (group I) was given 30% SDF and the second group (group II) were topically applied with 5% NaF solution. The fluoride concentration was measured in the salivary samples, which were collected at three time intervals, that is, at baseline (S1), 2 hours (S2), and 24 hours (S3) after application. Analysis of variance (ANOVA) test was used for evaluation and independent paired t-test was conducted for comparison between groups. Results: When using an ANOVA with repeated measures with a Greenhouse–Geisser correction, the mean scores of fluoride concentration were statistically significantly different at different time intervals for both NaF (F = 20.854, p < 0.0005) and SDF (F = 22.746, p < 0.0005). Conclusion: The present trial concluded that topical fluoride application increases fluoride bioavailability in saliva thereby increasing tooth remineralization. A steep rise in fluoride concentration was observed shortly post-SDF application at 2 hours and 24 hours time interval emerging a need for further research into the field of fluoridation with SDF.


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  1. Twetman S, Sköld-Larsson K, Modéer T. Fluoride concentration in whole saliva and separate gland secretions after topical treatment with three different fluoride varnishes. Acta Odontol Scand 1999;57(5):263–266. DOI: 10.1080/000163599428670
  2. Li X, Wang J, Joiner A, et al. The remineralisation of enamel: a review of the literature. J Dent 2014;42(Suppl 1):S12–S20. DOI: 10.1016/S0300-5712(14)50003-6
  3. Al Dehailan L, Lippert F, González-Cabezas C, et al. Fluoride concentration in saliva and biofilm fluid following the application of three fluoride varnishes. J Dent 2017;60:87–93. DOI: 10.1016/j.jdent.2017.03.005
  4. Byeon SM, Lee MH, Bae TS. The effect of different fluoride application methods on the remineralization of initial carious lesions. Restor Dent Endod 2016;41(2):121–129. DOI: 10.5395/rde.2016.41.2.121
  5. Oliveira BH, Rajendra A, Veitz-Keenan A, et al. The effect of silver diamine fluoride in preventing caries in the primary dentition: a systematic review and meta-analysis. Caries Res 2018;53(1):24–32. DOI: 10.1159/000488686
  6. Koo H. Strategies to enhance the biological effects of fluoride on dental biofilms. Adv Dent Res 2008;20(1):17–21. DOI: 10.1177/154407370802000105
  7. Trieu A, Mohamed A, Lynch E. Silver diamine fluoride versus sodium fluoride for arresting dentine caries in children: a systematic review and meta-analysis. Sci Rep 2019;9(1):2115. DOI: 10.1038/s41598-019-38569-9
  8. Horst JA, Ellenikiotis H, Milgrom PL. UCSF Protocol for caries arrest using silver diamine fluoride: rationale, indications and consent. J Calif Dent Assoc 2016;44(1):16–28. PMID: 26897901.
  9. Chu CH, Mei L, Seneviratne CJ, et al. Effects of silver diamine fluoride on dentine carious lesions induced by Streptococcus mutans and Actinomyces naeslundii biofilms. Int J Paediatr Dent 2011;22(1):2–10. DOI: 10.1111/j.1365-263X.2011.01149.x
  10. Cross KJ, Huq NL, Stanton DP, et al. NMR studies of a novel calcium, phosphate and fluoride delivery vehicle-alpha(S1)—casein(59-79) by stabilized amorphous calcium fluoride phosphate nanocomplexes. Biomaterials 2004;25(20):5061–5069. DOI: 10.1016/j.biomaterials.2004.01.045
  11. Chu CH, Lo EC, Lin HC. Effectiveness of silver diamine fluoride and sodium fluoride varnish in arresting dentin caries in Chinese pre-school children. J Dent Res 2002;81(11):767–770. DOI: 10.1177/0810767
  12. Dawes C, Weatherell JA. Kinetics of fluoride in the oral fluids. J Dent Res 1990;69:638–644. DOI: 10.1177/00220345900690S125
  13. Heijnsbroek M, Gerardu VA, Buijs MJ, et al. Increased salivary fluoride concentrations after post-brush fluoride rinsing not reflected in dental plaque. Caries Res 2006;40(5):444–448. DOI: 10.1159/000094292
  14. Vincent S, Thomas AM. Fluoride levels in saliva and plaque following the use of high fluoride and conventional dentifrices—a triple blinded randomised parallel group trial. ScientificWorldJournal 2019;2019:1636209. DOI: 10.1155/2019/1636209
  15. Rosenblatt A, Stamford TCM, Niederman R. Silver diamine fluoride: a caries “silver-fluoride bullet”. J Dent Res 2009;88(1):116–125. DOI: 10.1177/0022034508329406
  16. Naumova EA, Kuehnl P, Hertenstein P, et al. Fluoride bioavailability in saliva and plaque. BMC Oral Health 2012;6(1):112–115. DOI: 10.1186/1472-6831-12-3
  17. Vasquez E, Zegarra G, Chirinos E, et al. Short term serum pharmacokinetics of diammine silver fluoride after oral application. BMC Oral Health 2012;12:60. DOI: 10.1186/1472-6831-12-60
  18. Vogel GL. Oral fluoride reservoirs and the prevention of dental caries. Monogr Oral Sci 2011;22:146–157. DOI: 10.1159/000325166
  19. Weyant RJ, Tracy SL, Anselmo TT, et al. Topical fluoride for caries prevention: executive summary of the updated clinical recommendations and supporting systematic review. J Am Dent Assoc 2013;144(11):1279–1291. DOI: 10.14219/jada.archive.2013.0057
  20. Crystal YO, Janal MN, Hamilton DS, et al. Parental perceptions and acceptance of silver diamine fluoride staining. J Am Dent Assoc 2017;148(7):510–518.e4. DOI: 10.1016/j.adaj.2017.03.013
  21. Chu CH, Lo ECM. Microhardness of dentine in primary teeth after topical fluoride applications. J Dent 2008;36(6):387–391. DOI: 10.1016/j.jdent.2008.02.013
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