International Journal of Clinical Pediatric Dentistry

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VOLUME 14 , ISSUE 3 ( May-June, 2021 ) > List of Articles

RESEARCH ARTICLE

A Comparative Study of Salivary Flow Rate, pH, Buffer Capacity, Total Antioxidant Capacity, and Ferritin Levels in Children with Beta Thalassemia Major and Healthy Children

Guttikonda Venkateshwara Rao, Vem Preethi, Velagala Daneswari, Venugopal Reddy, Venumbaka Sivakalyan, Rajesh Garge

Citation Information : Rao GV, Preethi V, Daneswari V, Reddy V, Sivakalyan V, Garge R. A Comparative Study of Salivary Flow Rate, pH, Buffer Capacity, Total Antioxidant Capacity, and Ferritin Levels in Children with Beta Thalassemia Major and Healthy Children. Int J Clin Pediatr Dent 2021; 14 (3):342-348.

DOI: 10.5005/jp-journals-10005-1955

License: CC BY-NC 4.0

Published Online: 29-09-2021

Copyright Statement:  Copyright © 2021; The Author(s).


Abstract

Introduction: Thalassemia is a genetically diverse group of disease which occurs due to an imbalance in the production of the alpha and beta chains with ensuring chronic hemolysis, ineffective erythropoiesis, and iron overload. Aim and objective: The main aim of the study is to compare the salivary flow rate, pH, buffer capacity, total antioxidant capacity, and ferritin levels in children with beta thalassemia major and healthy children. Materials and methods: The present study includes 40 children consisting of 20 beta thalassemia major and 20 healthy children. Unstimulated saliva was collected by the spitting method. The salivary flow rate, pH, buffer capacity, total antioxidant capacity, and ferritin levels were evaluated. Results: Salivary ferritin levels were found to be higher in children with beta thalassemia major. Conclusion: Iron overload is also known as hemochromatosis which is one of the complications of thalassemia.


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  1. Maakaron JE, Cappellini MD, Taher AT. An update on thalassemia intermedia. J Med Liban 2013;61(3):175–182. DOI: 10.12816/0001447.
  2. Whipple GH, Bradford WL. Mediterranean disease – “thalassemia” [erythroblastic anaemia of cooley]; associated pigment abnormalities simulating hemochromatosis. J Pediatr 1936;9(3):279–311. DOI: 10.1016/S0022-3476(36)80021-3.
  3. Weatherall DJ. Thalassaemia: the long road from the bedside through laboratory to the community. Transfus Med 2011;21(4):218–223. DOI: 10.1111/j.1365-3148.2011.01090.x.
  4. Weatherall DJ. The thalassemia syndromes. Tex Rep Biol Med 1980;40:323–333.
  5. Kaufman E, Lamster IB. The diagnostic applications of saliva—a review. Crit Rev Oral Biol Med 2002;13(2):197–212. DOI: 10.1177/154411130201300209.
  6. Madhok S, Madhok S. Dental considerations in thalassemic patients. IOSR-JDMS 2014;13(6):57–62. DOI: 10.9790/0853-13645762.
  7. Dhote V, Thosar N, Baliga S. Evaluation of oral hygiene status and salivary biochemistry of patients with thalassemia major: a clinical study. IOSR-JDMS 2015;14(12):98–102.
  8. Dawes C. Physiological factors affecting salivary flow rate, oral sugar clearance, and the sensation of dry mouth in man. J Dent Res 1987;66(2_suppl):648–653. DOI: 10.1177/00220345870660S207.
  9. Pierto P, Pineda M, Aguilar M. Spectrophotometric quantification of antioxidant capacity through the formation of a phosphor-molybdenum complex; specific application to the determination of vitamin E. Anal Biochem 1999;269(2):337–341. DOI: 10.1006/abio.1999.4019.
  10. Kuriakose S, Sundaresan C, Mathai V, et al. A comparative study of salivary buffering capacity, flow rate, resting pH, and salivary immunoglobulin A in children with rampant caries and caries-resistant children. J Indian Soc Pedod Prev Dent 2013;31(2):69–73. DOI: 10.4103/0970-4388.115697.
  11. Koracevic D, Koracevic G, Djordjevic V, et al. Method for the measurement of antioxidant activity in human fluids. J Clin Pathol 2001;54(5):356–361. DOI: 10.1136/jcp.54.5.356.
  12. Salih KM, AL-Mosawy WF, Faraj YF, et al. Investigation of antioxidant status in Iraqi patients with beta thalassemia major. J Glob Pharma Technol 2017;7(9):109–113.
  13. Zubay G. Biochemistry. 4th ed., USA: Wm.C. Brown; 1998.
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