International Journal of Clinical Pediatric Dentistry

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VOLUME 14 , ISSUE 1 ( January-February, 2021 ) > List of Articles


Nonsyndromic with Recurrent Idiopathic Gingival Fibromatosis: A Rare Case Report

Amrita Kumari, Malvika B Bansal, Karan H Asrani, Ashish Yadav

Keywords : Gingival enlargement, Gingival fibromatosis, Gingivectomy, Hereditary

Citation Information : Kumari A, Bansal MB, Asrani KH, Yadav A. Nonsyndromic with Recurrent Idiopathic Gingival Fibromatosis: A Rare Case Report. Int J Clin Pediatr Dent 2021; 14 (1):158-160.

DOI: 10.5005/jp-journals-10005-1933

License: CC BY-NC 4.0

Published Online: 14-07-2021

Copyright Statement:  Copyright © 2021; Jaypee Brothers Medical Publishers (P) Ltd.


Idiopathic gingival fibromatosis is a genetic rare disorder, which is characterized by a progressive enlargement of the gingiva. Gingival enlargement is an overgrowth of the gingiva, which can be caused by various etiological factors such as poor oral hygiene, plaque accumulation, inadequate nutrition, hormonal stimulation, several blood dyscrasias, or long-term intake of certain drugs like phenytoin, nifedipine, or cyclosporine. A 14-year-old female patient reported to the Department of Periodontology, Mahatma Gandhi Dental College and Hospital, Jaipur, Rajasthan with her chief complaint of swollen gums in both upper and lower arches since 3 years, which was gradual in onset and increased in size since 4 months which covered almost half of the surface of each tooth. Also reported that 3 years ago, there was similar swelling for which surgical intervention in form of gingivectomy was carried out. The treatment plan for this case was followed by phase 1 therapy (scaling and root planing) and after completion of phase 1 therapy, the labial tissue from the mandibular anterior region was excised and sent for histopathological examination. Histopathological appearance revealed idiopathic gingival fibromatosis. Thereafter, the conventional gingivectomy under local anesthesia was performed to remove excess gingival overgrowth.

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  1. Coletta RD, Graner E. Hereditary gingival fibromatosis. A systematic review. J Periodontol 2006;77(5):753–764. DOI: 10.1902/jop.2006.050379.
  2. Jadhav AS, Marathe SP, Recurret idiopathic gingival fibromatosis with generalized aggressive periodontitis: A rare case report.
  3. Lai B, Muenzer J, Roberts MW. Idiopathic gingival hyperplasia: a case report with a 17-year follow up. Case Rep Dent 2011;2011:986237. DOI: 10.1155/2011/986237.
  4. Fletcher J. Gingival abnormalities of genetic origin: a preliminary communication with special reference to hereditary generalized gingival fibromatosis. J Dent Res 1966;45(3):597–612. DOI: 10.1177/00220345660450032401.
  5. Holzhausen M, Goncalves D, Correa Fde O, et al. A case of Zimmermann-Laband syndrome with supernumerary teeth. J Periodontol 2003;74(8):1225–1230. DOI: 10.1902/jop.2003.74.8.1225.
  6. Horning GM, Fisher JG, Barker BF, et al. Gingival fibromatosis with hypertrichosis: a case report. J Periodontol 1985;56(6):344–347. DOI: 10.1902/jop.1985.56.6.344.
  7. Korol UB, Schoor R, Nanda V, et al. Gingival enlargement as a manifestation of tuberous sclerosis case report and periodontal management. J Periodontol 2008;79(4):759–763. DOI: 10.1902/jop.2008.070407.
  8. Bozzo L, Machado MA, de Almeida OP, et al. Hereditary gingival fibromatosis: report of three cases. J Clin Pediatr Dent 2000;25(1):41–46. DOI: 10.17796/jcpd.25.1.e254616x22403280.
  9. Bozzo L, de Almedia OP, Scully C, et al. Hereditary gingival fibromatosis: report of an extensive four-generation pedigree. Oral Surg Oral Med Oral Pathol 1994;78(4):452–454. DOI: 10.1016/0030-4220(94)90037-x.
  10. Bittencourt LP, Campos V, Moliterno LF, et al. Hereditary gingival fibromatosis: review of the literature and a case report. Quintessence Int 2000;31(6):415–418.
  11. Nayak PA, Nayak UA, Khandelwal V, et al. Idiopathic gingival fibromatosis. Int J Clin Pediatr Dent 2011;4(1):77–81. DOI: 10.5005/jp-journals-10005-1086.
  12. Xiao S, Bu L, Zhu L, et al. A new locus for hereditary gingival fibromatosis (GINGF2) maps to 5q13-q22. Genomics 2001;74(2):180–185. DOI: 10.1006/geno.2001.6542.
  13. Hart TC, Pallos D, Bowden DW, et al. Genetic linkage of hereditary gingival fibromatosis to chromosome 2p21. Am J Hum Genet 1998;62(4):876–883. DOI: 10.1086/301797.
  14. Hart TC, Zhang Y, Gorry MC, et al. A mutation in the SOS1 gene causes hereditary gingival fibromatosis type 1. Am J Hum Genet 2002;70(4):943–954. DOI: 10.1086/339689.
  15. Singer SL, Goldblatt J, Hallam LA, et al. Hereditary gingival fibromatosis with a recessive mode of inheritance: case reports. Aust Dent J 1993;38(6):427–432. DOI: 10.1111/j.1834-7819.1993.tb04755.x.
  16. Anderson J, Cunliffe WJ, Roberts DF, et al. Hereditary gingival fibromatosis. BMJ 1969;3(5664):218–219. DOI: 10.1136/bmj.3.5664.218.
  17. Danesh-Meyer MJ, Holborow DW. Familial gingival fibromatosis: a report of two patients. N Z Dent J 1993;89(398):119–122.
  18. Clocheret K, Dekeyser C, Carels C, et al. Idiopathic gingival hyperplasia and orthodontic treatment: a case report. J Orthod 2003;30(1):13–19. DOI: 10.1093/ortho/30.1.13.
  19. Kavvadia K, Pepelassi E, Alexandridis C, et al. Gingival fibromatosis and significant tooth eruption delay in an 11-year-old male: a 30-month follow-up. Int J Paediatr Dent 2005;15(4):294–302. DOI: 10.1111/j.1365-263X.2005.00646.x.
  20. Ramer M, Marrone J, Stahl B, et al. Hereditary gingival fibromatosis; identification, treatment, control. J Am Dent Assoc 1996;127(4):493–495. DOI: 10.14219/jada.archive.1996.0242.
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