International Journal of Clinical Pediatric Dentistry

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VOLUME 13 , ISSUE 6 ( November-December, 2020 ) > List of Articles

Original Article

Variations in Physiological, Psychomotor, and Analgesic Parameters during Titration of Nitrous Oxide in 3–12 Years Old Children Managed with Inhalation Sedation

Shivangi Sharma, Radhika Chopra, Shivani Mathur, Vinod Sachdev, Kunal Gupta

Keywords : Analgesic parameter, Nitrous oxide, Physiological parameter, Psychomotor parameter

Citation Information : Sharma S, Chopra R, Mathur S, Sachdev V, Gupta K. Variations in Physiological, Psychomotor, and Analgesic Parameters during Titration of Nitrous Oxide in 3–12 Years Old Children Managed with Inhalation Sedation. Int J Clin Pediatr Dent 2020; 13 (6):650-655.

DOI: 10.5005/jp-journals-10005-1852

License: CC BY-NC 4.0

Published Online: 31-03-2021

Copyright Statement:  Copyright © 2020; Jaypee Brothers Medical Publishers (P) Ltd.


Background: The present study was designed to assess variations in physiological, psychomotor parameters, and analgesic effects at various levels of nitrous oxide-oxygen analgesia in 3–12 years old children. Design: One hundred children aged 3–12 years were assessed for physiological, psychomotor, and analgesic parameters at various concentrations of N2O, i.e., baseline, 20, 40, 50, and 0% (100% O2). Physiological, psychomotor, and analgesic effects were assessed using a pulse oximeter, bender visual-motor Gestalt test, and response to electric pulp tester, respectively. Results: Oxygen saturation (SpO2) showed a significant increase while heart rate (HR) showed a significant reduction at 50% N2O. No significant changes were observed in respiratory rate with a change in N2O levels. Significant reduction in the pain scores was found at the same level of stimulation by an electric pulp tester at 40 and 50% levels. The psychomotor changes were consistently higher at every concentration of nitrous oxide. However, no correlation could be found between various parameters tested. Conclusion: N2O caused a significant increase in SpO2 in both the age groups, a decrease in HR, a significant decrease in pain score at 40 and 50% concentration of N2O, and had a significant effect on the psychomotor ability of children.

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