Clinical and Radiographic Evaluation of 3Mix and Vitapex as Pulpectomy Medicament in Primary Molars: An In Vivo Study
Ramya Rai, Kukkalli K Shashibhushan, Prashant Babaji, Pradeep M Chandrappa, Vundela R Reddy, Zeenath Ambareen
Citation Information :
Rai R, Shashibhushan KK, Babaji P, Chandrappa PM, Reddy VR, Ambareen Z. Clinical and Radiographic Evaluation of 3Mix and Vitapex as Pulpectomy Medicament in Primary Molars: An In Vivo Study. Int J Clin Pediatr Dent 2019; 12 (6):532-537.
Objective: To evaluate the clinical and radiographic success rates of 3Mix and Vitapex in the treatment of necrosed primary teeth. Materials and methods: Seventy teeth of healthy children aged 4–9 years with necrotic primary molar (nonvital) were treated with 3Mix (lesion sterilization tissue repair therapy) and Vitapex before restoration with stainless steel crowns. The participants were followed up clinically and radiographically for 3 months and 6 months, respectively. The outcome was compared using Fisher exact test with a significance level of p < 0.05. Results: Clinical success rate of 3Mix group at 3 months and 6 month follow-up was 100% and 97.14% and that of Vitapex group was 100% and 100%, respectively. The radiographic success rate of 3Mix group at 3 months and 6 months was 74.29% and 77.14% and of Vitapex group was 97.14% and 97.14%, respectively. Considering the clinical success, no statistical difference was found between the two groups at the end of 6 month (p = 1.000). But radiographically statistical significant difference was found between the two groups (p = 0.028). Conclusion: Non-instrumentation endodontic treatment using 3Mix has shown a good clinical success of 97.14% but the radiographic success rate at 6 months was lower (77.14%). So it can be suggested that the use of 3Mix antibiotic treatment cannot replace conventional root canal treatment over the long term.
Waterhouse PJ, Whitworth JM, Camp JH, et al. Pediatric endodontics: Endodontics treatment for the primary and young permanent dentition. In Hargreaves KM, Cohen S, ed. Cohen's Pathways of the Pulp, 10th ed. Elsevier Publishers; 2011. pp. 808–857.
Nurko C, Garcia-Godoy F. Evaluation of a calcium hydroxide/iodoform paste (Vitapex) in root canal therapy for primary teeth. J Clin Pediatr Dent 1999;23(4):289–294.
Ozalp N, Saroglu I, Sonmez H. Evaluation of various root canal filling materials in primary molar pulpectomies: an in vivo study Am J Dent 2005;18(6):347–350.
Nurko C, Ranly DM, Garcia-Godoy F. Resorption of a calcium hydroxide/iodoform paste (Vitapex) in root canal therapy for primary teeth: a case report. Pediatr Dent 2000;22(6):517–520.
Nakornchai S, Banditsing P, Visetratana N. Clinical evaluation of 3 Mix and vitapex as treatment options for pulpally/involved primary molars. Int J Paediatr Dent 2010;20(3):214–221. DOI: 10.1111/j.1365-263X.2010.01044.x.
Sato I, Kurihara NA, Kota K, et al. Sterilization of infected root-canal dentine by topical application of a mixture of ciprofloxacin, metronidazole and minocycline in situ. Int Endod J 1996;29(2): 118–124. DOI: 10.1111/j.1365-2591.1996.tb01172.x.
Pinky C, Shashibhushan KK, Subbareddy VV. Endodontic treatment of necrosed primary teeth using two different combinations of antibacterial drugs: an in vivo study. J Indian Soc Pedod Prev Dent 2011;29(2):121–127. DOI: 10.4103/0970-4388.84684.
Prabhakar AR, Sridevi E, Raju OS, et al. Endodontic treatment of primary teeth using combination of antibacterial drugs: an in vivo study. J Indian Soc Pedod Prev Dent 2008;26(1):5–10. DOI: 10.4103/0970-4388.40313.
Takushige T, Cruz EV, Moral AA, et al. Endodontic treatment of primary teeth using a combination of antibacterial drugs. Int Endod J 2004;37(2):132–138. DOI: 10.1111/j.0143-2885.2004.00771.x.
Kargül B, Kadir T. The antibacterial effects of ornidazole on primary molars with infected pulps. Chemotherapy 2001;47(3):203–207. DOI: 10.1159/000063222.
Cruz EV, Kota K, Huque J, et al. Penetration of propylene glycol into dentine. Int Endod J 2002;35(4):330–336. DOI: 10.1046/j.1365-2591.2002.00482.x.
Nanda R, Koul M, Srivastava S, et al. Clinical evaluation of 3 Mix and Other Mix in non-instrumental endodontic treatment of necrosed primary teeth. J Oral Biol Craniofac Res 2014;4(2):114–119. DOI: 10.1016/j.jobcr.2014.08.003.
Trairatvorakul C, Detsomboonrat P. Success rates of a mixture of ciprofloxacin, metronidazole, and minocycline antibiotics used in the non-instrumentation endodontic treatment of mandibular primary molars with carious pulpal involvement. Int J Paediatr Dent 2012;22(3):217–127. DOI: 10.1111/j.1365-263X.2011.01181.x.
Duanduan A. Retrospective study of pulpectomy with Vitapex and LSTR with three antibiotics combination (3mix) for non vital pulp treatment in primary teeth. CMU J Nat Sci 2013;12(2):131–139. DOI: 10.12982/CMUJNS.2013.0012.
Theerapiboon U. Pulp Therapy in Primary Teeth with Three Mix Antibiotics. Chiang Mai Dent J 2012;33(1):15–27.
Mortazavi M, Mesbahi M. Comparison of zinc oxide and eugenol, and Vitapex for root canal treatment of necrotic primary teeth. Int J Paediatr Dent 2004;14:417–424. DOI: 10.1111/j.1365-263X.2004.00544.x.
Qadeer S, Munir B, Dar SY. Comparison Of Effectiveness Of Triple Antibiotic Paste (3mix) And Vitapex For Root Canal Treatment Of Pulpally Involved Primary Molars. Pak Oral Dent J 2016;36(4): 654–657.
