International Journal of Clinical Pediatric Dentistry

Register      Login

SEARCH WITHIN CONTENT

FIND ARTICLE

Volume / Issue

Online First

Archive
Volume  17 (2024)
Volume  16 (2023)
Volume  15 (2022)
Volume  14 (2021)
Volume  13 (2020)
Volume  12 (2019)
Volume  11 (2018)
Volume  10 (2017)
Volume  9 (2016)
Volume  8 (2015)
Volume  7 (2014)
Volume  6 (2013)
Volume  5 (2012)
Volume  4 (2011)
Volume  3 (2010)
Volume  2 (2009)
Volume  1 (2008)
Related articles

VOLUME 8 , ISSUE 2 ( May-August, 2015 ) > List of Articles

CASE REPORT

Oral and Dental Considerations in Management of Sickle Cell Anemia

Sonu Acharya

Keywords : Dental management, Oral considerations, Sickle cell anemia, Sickling

Citation Information : Acharya S. Oral and Dental Considerations in Management of Sickle Cell Anemia. Int J Clin Pediatr Dent 2015; 8 (2):141-144.

DOI: 10.5005/jp-journals-10005-1301

License: CC BY-NC 4.0

Published Online: 01-07-2019

Copyright Statement:  Copyright © 2015; The Author(s).


Abstract

Sickle cell anemia is a genetic disease that primarily affects the black population. This anemia is due to a homozygous state of the abnormal hemoglobin S. An alteration occurs on the DNA molecule involving the substitution of the amino acid valine for glutamic acid at the sixth position on the beta polypeptide chain. This biochemical variation on the DNA molecule creates a physiological change that causes sickle-shaped red blood cells to be produced. The sickle-shaped cells are the result of the hemoglobin S being deoxygenated. This case report presents a case of 16-year-old female with sickle cell disease and its dental management. How to cite this article: Acharya S. Oral and Dental Considerations in Management of Sickle Cell Anemia. Int J Clin Pediatr Dent 2015;8(2):141-144.

PDF Share
  1. Steinberg MH. Genetic etiologies for phenotypic diversity in sickle cell anemia. Sci World J 2009;9(1):46-49.
  2. Williams TN, Uyoga S, Macharia A, Ndila C, McAuley CF, Opi DH, et al. Bacteraemia in Kenyan children with sickle cell anaemia: a retrospective cohort and case-control study. Lancet 2009;374:1364-1369.
  3. Nagel RL, Fabry ME, Steinberg MH. The paradox of hemoglobin SC disease. Blood Review 2003;17(3):167-178.
  4. Rouse LE, Hays GL: Dental considerations in sickle cell anemia. Gen Dent 1979;27(6):18-19.
  5. Pace BS, Zein S. Understanding mechanisms of gamma-globin gene regulation to develop strategies for pharmacological fetalhemoglobin induction. Developmental dynamics 2006; 235(7):1727-1737.
  6. Hebbel RP, Osarogiagbon R, Dhananjay K. The endothelial biology of sickle cell disease: inflammation and a chronic vasculopathy. Microcirculation 2004;11(11):129-151.
  7. Serjeant GR. Geography and the clinical picture of sickle cell disease. An overview. Ann NY Acad Sci 1989;565(2):109-119.
  8. Embury SH. The clinical pathophysiology of sickle cell disease. Annu Rev Med 1986;37:361-376.
  9. Smith JA. The natural history of sickle cell disease. Ann NY Acad Sci 1989;565:104-108.
  10. Cullen CL. Sickle cell anemia: dental management of the child patient. J Mich Dent Assoc 1982;64(2):77-78.
  11. Smith HB, McDonald DK, Miller RI: dental management of patients with sickle cell disorders. J Am Dent Assoc 1987;114(1):85M-87.
  12. Luna ACA, Rodrigues MJ, Menezes VA, Marques KMG, Santos FA. Caries prevalence and socioeconomic factors in children with sickle cell anemia. Braz Oral Res 2012;26(1): 43-49.
  13. Kavadia-Tsatala S, Kolokytha O, Kaklamanos EG, Antoniades K, Chasapopoulou E. Mandibular lesions of vasoocclusive origin in sickle cell hemoglobinopathy. Odontol 2004;92(1):68-72.
  14. Gillis MV, West NM. Sickle cell disease and trait: an increase in trabecular spacing, a case study. J Dent Hygiene 2004;78(2): 355-359.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.