The melanotic neuroectodermal tumor of infancy (MNTI) is a rare benign neoplasm of neural crest origin most commonly found in the anterior region of the maxilla. The tumor almost always develops during the first year of life, although in some cases it can be present at birth. MNTI's present as a rapidly growing, painless expansile, partly pigmented mass. They are usually unencapsulated, with a tendency to occur as a single lesion. Local excision is the treatment of choice and is usually curative. Main sites for recurrences are the maxilla (57%) and the skull/brain (28.6%). Malignant transformation has been noted in approximately 6.5% of all cases and in 2% of maxillary tumors. The case of a 3-month old boy who presented with a loose primary maxillary left central incisor is discussed. The diagnostic and clinico-pathological features as well as tumor management and importance of a timely diagnosis are reviewed.
Liu HH, Chen TW, Chang HS. Melanotic neuroectodermal tumor of infancy in the maxilla: A case report. Int J Paediatr Dent 2004 Sep;14(5):371-375.
Krombecher E. Zur histogenese and morphologie der adamantonime and sonstiger kiefergeschwulste. Pathol Anat Allg Pathol 1918;64:165-197.
Cutler LS, Chaudhry AP, Topazian R. Melanotic neuroectodermal tumor of infancy: An ultrastructural study, literature review, and reevaluation. Cancer 1981 Jul 15;48(2):257-270.
Sapp, JP.; Eversole, LR.; Wysocki, GP. Contemporary oral and maxillofacial pathology. St. Louis: Mosby; 1997. 299 p.
Neville, BW.; Damm, DD.; Allen, CA.; Bouquot, JE. Oral and maxillofacial pathology. Philadelphia: WB Saunders; 1995. p. 385-386.
Kruse-Losler B, Gaertner C, Burger H, Seper L, Joos U, Kleinheinz J. Melanotic neuroectodermal tumor of infancy: systematic review of the literature and presentation of a case. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006 Aug; 102(2):204-216.
Dehner LP, Sibley RK, Sauk JJ Jr, Vickers RA, Nesbit ME, Leonard AS, Waite DE, Neeley JE, Ophoven J. Malignant neuroectodermal tumor of infancy: A clinical, pathological, ultrastructural and tissue culture study. Cancer 1979 Apr;43(4): 1389-1410.
Tan O, Atik B, Ugras S. Melanotic neuroectodermal tumor in a newborn. Int J Pediatr Otorhinolaryngol 2005 Oct;69(10): 1441-1444.
Shaia WT, Dinardo LJ, Underhill TE, Cesca CE. Recurrent melanotic neuroectodermal tumor of infancy. Am J Otolaryngol 2002 Jul-Aug;23(4):249-252.
Borello ED, Gorlin RJ. Melanotic neuroectodermal tumor of infancy--A neoplasm of neural crest origin. Report of a case associated with high urinary excretion of vanilmandelic acid. Cancer 1966 Feb;19(2):196-206.
Mellor GW, Gallacher G. Fluorescence polarization immunoassay of urinary vanillylmandelic acid. Clin Chem 1990 Jan;36(1): 110-112.
Puchalski R, Shah UK, Carpentieri D, McLaughlin R, Handler SD. Melanotic neuroectodermal tumor of infancy (MNTI) of the hard palate: Presentation and management. Int J Pediatr Otorhinolaryngol 2000 Jun 30;53(2):163-168.
Woessmann W, Neugebauer M, Gossen R, Blutters-Sawatzki R, Reiter A. Successful chemotherapy for melanotic neuroectodermal tumor of infancy in a baby. Med Pediatr Oncol 2003 Mar;40(3):198-199.
