International Journal of Clinical Pediatric Dentistry

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VOLUME 3 , ISSUE 1 ( January-April, 2010 ) > List of Articles

CASE REPORT

Dental Considerations in the Management of Glanzmann’s Thrombasthenia

Diana N Mehta

Citation Information : N Mehta D. Dental Considerations in the Management of Glanzmann’s Thrombasthenia. Int J Clin Pediatr Dent 2010; 3 (1):51-56.

DOI: 10.5005/jp-journals-10005-1054

License: CC BY-NC 4.0

Published Online: 01-06-2018

Copyright Statement:  Copyright © 2010; The Author(s).


Abstract

Glanzmann’s thrombasthenia, is one of the rarest congenital, genetically inherited platelet disorder. It has an incidence of about 1:1,000,000, but is more common in populations with increased consanguinity. Glanzmann’s thrombasthenia is characterized by deficiency or dysfunction of glycoprotein (GP) IIb and IIIa, which are the receptors of fibrinogen. Both sexes are equally affected. Typical mucocutaneous bleeding occurs at birth or early infancy. Obtaining appropriate dental history of excessive bleeding after dental extraction, unexplained spontaneous mucocutaneous bleeding, gingival bleeding during teething or shedding of deciduous teeth and petechiae, ecchymoses or purpura on mucous membranes can play an important part in diagnosis. Hence, the pediatric dentist plays a very crucial role for prompt diagnosis and management of Glanzmann’s thrombasthenia. Presenting here is a known case of Glanzmann’s thrombasthenia, of a 6-year-old girl who required to undergo dental extraction and its successful management using an “acrylic-splint” along with the placement of “Calgigraf-Ag Foam”.


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  1. Caen JP, Castaldi PA, Leclrec JC, Inceman S, Larrieu MJ, Probst M, Bernard J. Congenital bleeding disorders with long bleeding time and normal platelet count. I. Glanzmann’s Thrombasthenia: Report of 15 patients. Am J Med 1966 Jul;41(1):4-26
  2. Glanzmann Thrombasthenia. J Coag Hemost Dis 2006;1:2-10
  3. Glanzmann Thrombasthenia: A model disease which paved the way to powerful therapeutic agents. Pathophysiol Haemost Thromb 2002 Sep-Dec;32(5-6):216-217
  4. Glanzmann’s Thrombasthenia. J Postgrad Med 1980 Jul;26(3):210-212
  5. ; Beutler, E.; Ersler, AJ, et al. Disorders of Hemostatis. In: Hematology. 2nd ed. New York: Mc Graw-Hill; 1977. p. 1368-1376
  6. Glanzmann Thrombasthenia: A rare hematological disorder with oral manifestations: a case report. J Contemp Dent Pract 2008 Jul;(9)5:107-113
  7. Dental considerations for a Glanzmann’s Thrombasthenia patient: case report. J Periodontol 1996 May;67(5):536-540
  8. Glanzmann’s Thrombasthenia associated with HBsAg-positive child: A case report. J Indian Soc Pedod Prev Dent 2007;25 Suppl:37-40
  9. ; Shapiro, AD.; Hock, RA., et al. Management of the medically compromised patient: Hematologic disorders, Cancer, Hepatitis and AIDS. In: McDonald, Avery, Dean. Dentistry for the Child and Adolescent. 8th ed. St. Louis: Mosby; 2004. pp. 559–564.
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