Aim: The aim of this in vitro study is to evaluate the remineralizing potential of commonly used fluoridated toothpaste, toothpaste with calcium sucrose phosphate, toothpaste with zinc hydroxyapatite, herbal toothpaste, and to compare them. Background: The process of demineralization and remineralization is balanced and occurs concurrently in the oral cavity, but even a mild disruption in this mechanism could lead to dental caries. Dental caries is a threat in the Third World countries and more common entity in childhood. The caries prevalence is reported to be 41% for children within the age of 2–11 years. Materials and method: According to previous studies and standard sample size calculating formula the sample size of 48 was calculated, the teeth were subjected to demineralization – remineralization process and were observed under scanning electron microscope. Results: The outcomes of this study suggest that the remineralizing potential of toothpaste with zinc hydroxyapatite (p = 0.0001*) was highest as compared to toothpaste with fluoride ( p = 0.0087*), herbal toothpaste ( p = 0.9034), and toothpaste with calcium sucrose phosphate (p = 0.0002*). Conclusion: All the four toothpastes showed an adequate amount of remineralization but the highest amount of remineralization potential was seen with toothpaste containing zinc hydroxyapatite. Clinical significance: The clinical significance of our study is to give clear and evidence-based idea to the dentist and the parents about the remineralizing toothpaste available in the market for children. Treating demineralization at an initial stage would help to remineralize the tooth structure and thereby limit further destruction of the tooth structure which will preserve the beautiful smile of the child.