Osteopetrosis is a rare genetic disorder that causes generalized sclerosis of bone due to a defect in bone resorption and remodeling. It is usually manifesting in two basic forms: An autosomal dominant benign form (osteopetrosis tarda) and an autosomal recessive malignant form (osteopetrosis congenita). A third form, the intermediate recessive type, has also been reported. Dental abnormality may be attributed to pathological changes in bone remodeling. Osteomyelitis is well documented as a complication of osteopetrosis and is severe and difficult to treat. This is a case of 8-year-old boy with osteopetrosis presenting with the complaint of swelling of left side of face.
Langlais RP, Langland OE, Nortje CJ. Generalised radiopacities: Osteopetrosis. In: Langlais, Langland, Nortje (Eds). Diagnostic imaging of the jaws. Malvern, USA: Williams and Wilkins; 1995:598-13.
Krimmel M, Niemann G, Will B, Reinert S. Surgical correction of craniosynostosis in malignant osteopetrosis. J Craniofac Surg 21.
Bakeman RJ, Abdelsayed RA, Sutley SH, Newhouse RF. Osteopetrosis: A review of the literature and report of a case complicated by osteomyelitis of the mandible. J Oral Maxillofac Surg 1998;56:1209-13.
Batra P, Shah N. Recalcitrant osteomyelitis following tooth extraction in a case of malignant osteopetrosis. Int Dent J 2004;54:418-23.
Dick HM, Simpson WJ. Dental changes in osteopetrosis. Oral Surg 1972;32:408-16.
Lazner F, Gowen M, Pavasovic D, Kola I. Osteopetrosis and osteoporosis: Two sides of the same coin. Hum Mol Genet 1999;8:1839-46.
Gorlin RJ, Cohen MM, Levin LS. Syndromes of the head and neck (3rd ed). Oxford University press, p. 232-34.
Roopashri RK, Gopakumar R, Subhas BG. Osteomyelitis in infantile osteopetrosis: A case report with review of literature. J Indian Soc Pedod Prev Dent (serial online) 2008 (cited 2009, Aug 24);26:125-28.