International Journal of Clinical Pediatric Dentistry

Register      Login

VOLUME 4 , ISSUE 2 ( May-August, 2011 ) > List of Articles

REVIEW ARTICLE

Gene Therapy and its Implications in Dentistry

AR Prabhakar, Jibi M Paul, N Basappa

Keywords : Gene therapy, Gene transfer, Bone repair, Salivary glands, Cancer, Pain, Keratinocytes, DNA vaccination, Orthodontic tooth movement

Citation Information : Prabhakar A, Paul JM, Basappa N. Gene Therapy and its Implications in Dentistry. Int J Clin Pediatr Dent 2011; 4 (2):85-92.

DOI: 10.5005/jp-journals-10005-1088

License: CC BY-NC 4.0

Published Online: 00-08-2011

Copyright Statement:  Copyright © 2011; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Background: The concept of transferring genes to tissues for clinical applications has been discussed for nearly half a century. The exponential increase in our ability to manipulate the genetic material of a cell via recombinant DNA technology has brought this goal closer to realization. The original perception that gene therapy should be considered only for a few major organs as a means of treating life-threatening disorders that are refractory to conventional treatment has changed. There are many non-life-threatening conditions that adversely affect a patient\'s quality of life, for which there are no effective treatments. The lack of suitable treatment has permitted morbidity to become a rational basis for extending the scope of gene therapy. In the past few years, remarkable progress has been made in the field of gene therapy. While considerable problems remain, thus impeding the routine clinical use of gene transfer, gene therapy will have a pervasive and significant impact on areas that are based on biological science. Aim: The purpose of this review is to examine the progress made in addressing gene transfer strategies for correcting various diseases and problems that are relevant to dental practice.


PDF Share
  1. Fry WJ, Wood KJ. Gene therapy: Potential applications in clinical transplantation. URL: http//www-ermm.cbcu.cam.ac.uk/99000691h.htm. Accessed on 7 January 2009.
  2. Baum JB, O'Connel CB. The impact of gene therapy on dentistry. JADA 1995;126:179-89.
  3. Berg P. Molecular genetics: Gene organization, regulation, and manipulation. In: Gelehrter DT, Colllins SF (Eds). Principles of medical genetics. Williams & Wilkins, Baltimore, sMaryland 1990:89-91.
  4. Breau LB, Clayman LG. Gene replacement therapy. In: Harrison BL, Sessions BR, Hong KW (Eds). Head and neck cancer, A multidisciplinary approach (6th ed). Lippincott Williams & Wilkins 2004:1018-28.
  5. Iskander A, Yoo HG. Gene therapy for patients with head and neck cancer. Adelstein JD (Ed). Squamous cell head and neck cancer. Humana press, Totowa, Newjercey 2005:263-78.
  6. Baum JB, Kok M, Tran DS, Yamano S. The impact of gene therapy on dentistry. JADA 2002;133:35-44.
  7. URL. http://en.wikipedia.org/wiki/Gene_therapy. Accessed on 21 December 2008.
  8. Karthikeyan VB, Pradeep RA. Gene therapy in periodontics. A review and future implications. The J Contemporary Dental Practice 2006:7(3):83-91.
  9. Franceschi TR. Biological approaches to bone regeneration by gene therapy. J Dental Research 2005;84(12):1093-1103.
  10. Luo J, et al. Gene therapy for bone regeneration. Current gene therapy 2005;5:167-79.
  11. Kirker AC. Potential applications and delivery strategies for bone morphogenetic proteins. Advanced drug delivery reviews 2000;43:65-69.
  12. Cho TJ, Gerstenfeld LC, Einhorn TA. Differential temporal expression of members of the transforming growth factor beta superfamily during murine fracture healing. J Bone Miner Res 2002;17:513-20.
  13. Reddi AH. Bone and cartilage differentiation. Curr Opin Genet Dev 1994;4:737-44.
  14. Bruder SP, Horowitz MC, Mosca JD, Haynesworth SE. Monoclonal antibodies reactive with human osteogenic cell surface antigens. Bone 1997;21:225-35.
  15. Peng H, et al. Synergistic enhancement of bone formation and healing by stem cell-expressed VEGF and bone morphogenetic protein-4. J Clin Invest 2003;110:751-59.
  16. Zuk PA, et al. Multilineage cells from human adipose tissue: Implications for cell-based therapies. Tissue Eng 2003;7: 211-28.
  17. Rutherford RB, et al. Bone morphogenetic protein-transduced human fibroblasts convert to osteoblasts and form bone in vivo. Tissue Eng 2003;8:441-45.
  18. Phillips EJ, Gersbach EC, García JA. Virus-based gene therapy strategies for bone regeneration. Biomaterials 2007;28:211-29.
  19. Kagami H, Wang S, Hai B. Restoring the function of salivary glands. Oral diseases 2008;14:15-24.
  20. Simmons KR, Baum JM. Transferring genes to salivary glands. J Dental Education 2001;65:907-10.
  21. Zufferey R, Aebischer P. Sal glands and gene therapy: The mouth waters. Gene Therapy 2004;11:1425-26.
  22. Atkinson CJ, Baum JB. Salivary enhancement: Current status and future therapies. J Dental Education 2001;65(10):1096-101.
  23. Vitolo MJ, Baum JB. The use of gene transfer for the protection and repair of salivary glands. Oral Diseases 2002;8:183-91.
  24. Ganly I, Soutar DS, Kaye SB. Current role of gene therapy in head and neck cancer. Europ J Surgical Oncology 2000;26: 338- 43.
  25. Vattemi E, Claudio PP. Adenoviral gene therapy in head and neck cancer. Drug News Perspect 2006;19(6).
  26. Gleich LL. Molecular genetics of head and neck cancer. Cancer Control 2002;9(5):369-78.
  27. Liu1 TC, Kirn D. Gene therapy progress and prospects cancer: Oncolytic viruses. Gene Therapy 2008;15:877-84.
  28. Pohl M, Fin DJ. A new player in gene therapy for pain. Gene Therapy 2008;15:953-54.
  29. Rice J. Gene therapy for chronic pain. URL: http//www.technologyreview.com/biomedicine/20118/. Accessed 21 December 2008.
  30. Kuboki AT, Nakanishi T, Kanyama M, et al. Direct adenovirusmediated gene delivery to the temporomandibular joint in guinea-pigs. Arch Oral Biol 1999;44:701-09.
  31. Garlick JA, Fenjves ES. Keratinocyte gene transfer and gene therapy. Crit Rev Oral Biol Med 1996;7(3):204-21.
  32. Vailly J, et al. Corrective gene transfer of keratinocytes from patients with junctional epidermolysis bullosa restores assembly of hemidesmosomes in reconstructed epithelia. Gene Therapy 1998;5:1322-32.
  33. Rutherford BR, Racenis P, Fatherazi S, Izutsu K. Bone formation by BMP-7-transduced human gingival keratinocytes. J Dent Res 2003;82(4):293-97.
  34. Yonezawa H, Ishihara K, Okuda K. Arg-Gingipain A DNA vaccine induces protective immunity against infection by porphyromonas gingivalis in a murine model. Infection and Immunity 2001:2858-64.
  35. Jia R, et al. Mucosal immunization against dental caries with plasmid DNA encoding pac gene of streptococcus mutans in rats. Vaccine 2004;22:2511-16.
  36. Fan MW, Bian Z, Peng ZX, Zhong Y, Chen Z, Peng B, et al. DNA vaccine encoding streptococcus mutans surface protein protected gnotobiotic rats from caries. J Dent Res 2002; 81(11):784-87.
  37. Havens B, Wadhwa S, Nanda R. Orthodontics in the year 2047: Genetically driven treatment plans. JCO 2007;41(9):549-56.
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.