International Journal of Clinical Pediatric Dentistry

Register      Login

VOLUME 3 , ISSUE 3 ( September-December, 2010 ) > List of Articles

ORIGINAL ARTICLE

Evaluation of Parental Nasomaxillary Asymmetry as a Risk Factor for Development of Palatal Clefts in their Offsprings

Dinesh Kumar S, K Gopalkrishnan, C Bhasker Rao, Sanjay V Ganeshkar

Citation Information : Kumar S D, Gopalkrishnan K, Bhasker Rao C, V Ganeshkar S. Evaluation of Parental Nasomaxillary Asymmetry as a Risk Factor for Development of Palatal Clefts in their Offsprings. Int J Clin Pediatr Dent 2010; 3 (3):163-171.

DOI: 10.5005/jp-journals-10005-1072

License: CC BY-NC 4.0

Published Online: 01-09-2010

Copyright Statement:  Copyright © 2010; The Author(s).


Abstract

Background and Objectives : It has been suggested previously that increased width of midfacial structure is associated with the development of palatal clefting. One of the most important heritable characteristics predisposing towards the development of orofacial clefting in an embryo is craniofacial morphology. The aim of the study was to compare nasomaxillary width of parents of children with unilateral complete cleft lip alveolus and palate with parents of noncleft children. Methods : 25 biologic parent sets of children with unilateral complete cleft lip alveolus and palate and 25 biologic parents of noncleft children were included in this study for PA cephalometric analysis. Results : There was no statistically significant difference between study and control groups. An association was found between the side of the cleft in the affected children and the parents in the same side with narrower nasomaxillary width. Interpretation and conclusion : The result of this study was in contrast with other previous studies. We observed a narrower nasomaxillary width, which suggested that this feature may be of morphogenetic importance in the etiopathogenesis of orofacial clefting in this geographic and ethnic group.


PDF Share
  1. Fraser FC, Pashayan H. Relation of face shape to susceptibility to congenital cleft lip. A preliminary report. J Med Genet 1970 Jun;7(2):112-117
  2. Asymmetry of the human facial skeleton. Angle Orthod 1975 Apr;45(2):125-129
  3. An Assessment of asymmetry in the normal craniofacial complex. Angle Orthod 1978 Apr;48(2):141-148
  4. Characteristics of craniofacial structures of parents of children with cleft lip and/or palate. Am J Orthod 1983 Aug;84(2):140-146
  5. A frontal asymmetry analysis. J Clin Orthod 1987 Jul;21(7):448-465
  6. Parental data used to predict growth of craniofacial form. Am J Orthod Dentofacial Orthop 1991 Feb;99(2):107-121
  7. Craniofacial pattern of parents of children having cleft lip and/or palate anomaly. Angle Orthod 1994;64(2):137-144
  8. Differentiation between cleft lip with or without cleft palate and isolated cleft palate using parental cephalometric parameters. Cleft Palate Craniofac J 1997 Jan;34(1):27-35
  9. Mandibular and maxillary asymmetry in individuals with unilateral cleft lip and palate. Cleft Palate Craniofac J. 1997 May;34(3):232-239
  10. Cephalometric features in the parents of children with orofacial clefting. Br J Oral Maxillofac Surg 1998 Jun;36(3):202-212
  11. Craniofacial variability in parents of children with cleft lip and cleft palate. J Clin Pediatr Dent 1999;23(4):337-341
  12. Posteroanterior cephalometric analysis of the parental craniofacial morphology in orofacial clefting. Cleft Palate Craniofac J 2003 Jul;40(4):416-425
  13. Association of nasomaxillary asymmetry in children with unilateral cleft lip and palate and their parents. Cleft Palate Craniofac J 2003 Sep;40(5):493-497.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.