International Journal of Clinical Pediatric Dentistry

Register      Login

VOLUME 3 , ISSUE 1 ( January-April, 2010 ) > List of Articles

ORIGINAL ARTICLE

Dental Development in Patients with Hypophosphatemic Rickets

AI-Jundi SH, Hazza’a AM

Citation Information : SH A, AM H. Dental Development in Patients with Hypophosphatemic Rickets. Int J Clin Pediatr Dent 2010; 3 (1):1-4.

DOI: 10.5005/jp-journals-10005-1046

License: CC BY-NC 4.0

Published Online: 01-01-2010


Abstract

Background : Hypophosphatemic Rickets (HR) is a disease that affects mineralized structures including bone and dentine, studies on dental development in these patients are scarce with equivocal results. Aim : To assess dental development of a group of children with (HR) and to compare that to healthy matched controls, and to assess relationship between delayed medical treatment and dental development. Materials and methods : This is a controlled cross-sectional study carried out on a sample of 21 children with HR and healthy age and sex matched controls, diseased children were diagnosed at different ages. Dental age was assessed using Demirjian et al method. The difference between ages of study and control groups was assessed using t-test, Pearson correlation was used to test relationship between age of commencement of treatment and dental development delay. Results : Most HR subjects demonstrated dental delay ranging from 0.2 to 2.5 years which was significant (p-value = 0.028). The difference between dental age of the study and control groups was statistically significant using paired t-test. There was no correlation between age of commencement of treatment and amount of dental delay. Conclusion : Dental development was significantly delayed in a group of HR patients compared to matched healthy controls. Delay in commencement of treatment may lead to a permanent deficit in dental development.


PDF Share
  1. Rowe PS. The molecular background to hypophosphataemic rickets. Arch Dis Child 2000 Sep;83(3):192-194
  2. Hypophosphatemic rickets and osteomalacia. Arq Bras Endocrinol Metabol 2006 Aug;50(4):802-813
  3. The spectrum of dental manifestations in vitamin D-resistant rickets: implications for management. Pediatr Dent 1986 Sep;8(3):245-250
  4. Prevalence of dental abscess in a population of children with vitamin D-resistant rickets. Pediatr Dent 1991 Mar-Apr;13(2):91-96
  5. Pathohistology of undecalcified primary teeth in vitamin D-resistant rickets: review and report of two cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1996 Aug;82(2):218-224
  6. Clinical course of hypophosphatemic rickets in 23 adults. Clin Nephrol 1996 Jan;45(1):33-41
  7. Dental problems associated with hypophosphataemic vitamin D resistant rickets. Int J Pediatr Dent 1998 Mar;8(1):19-28
  8. Micromorphologic features of dentin in vitamin D-resistant rickets: correlation with clinical grading of severity. Pediatr Dent 1989 Sep;11(3):203-208
  9. Scanning electron microscopic analysis of dentin in vitamin D-resistant rickets: assessment of mineralization and correlation with clinical findings. Pediatr Dent 1991 Jan-Feb;13(1):43-48
  10. Effect of familial hypophosphatemic rickets on dental development: a controlled, longitudinal study. Pediatr Dent 1995 Sep-Oct;17(5):346-350
  11. Craniofacial morphology in patients with hypophosphatemic vitamin-D-resistant rickets: a cephalometric study. J Oral Rehabil 2009 Jul;36(7):483- 490
  12. A new system of dental age assessment. Hum Biol 1973 May;45(2):211-227
  13. Dentofacial development in children with vitamin D-resistant rickets. J Am Dent Assoc 1968 May;76(5):1026-1031
  14. A genetic study of familial hypophosphatemia and vitamin D resistant rickets with a review of the literature. Medicine (Baltimore) 1958 May;37(2):97-142
  15. Dental observations in vitamin D-resistant rickets with special reference to periapical lesions. J Endod 1985 Nov;11(11):514-520
  16. The effect of phosphate supplementation on linear growth in children with X-linked hypophosphatemia. Pediatrics 1994 Oct;94(4 Pt 1):478-481
  17. X-linked hypophosphatemia: the mutant gene is expressed in teeth as well as in kidney. Am J Hum Genet 1990 Mar;46(3):434-442.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.