Background: The use of saliva to identify individuals with disease and to follow the progress of the affected individual has attracted the attention of numerous investigators. Its noninvasive method of collection, simplicity, and cost effectiveness make it a useful tool not only to the general practitioner but also to the pediatric dentist.
Aim: The aim of this paper is to provide the clinician with a comprehensive review of the diagnostic uses of saliva in dentistry.
Aguirre A, Testa-Weintraub LA, Banderas JA, Haraszthy GG, Reddy MS, Levine MJ. Sialochemistry: A diagnostic tool? Crit Rev Oral Biol Med 1993;4(3-4):343-350.
Mandel ID. The diagnostic uses of saliva. J Oral Pathol Med 1990 Mar;19(3):119-125.
Kaufman E, Lamster IB. Diagnostic applications of saliva---A review. Crit Rev Oral Biol Med 2002;13(2):197-212.
Slavkin HC. Toward molecularly based diagnostics for the oral cavity. J Am Dent Assoc 1998 Aug;129(8):1138-1143.
Llena-Puy C. The role of saliva in maintaining oral health and as an aid to diagnosis. Med Oral Patol Oral Cir Bucal 2006 Aug; 11(5):E449-E455.
Mandel ID. Salivary diagnosis: More than a lick and a promise. J Am Dent Assoc 1993 Jan;124(1):85-87.
Li Y, Denny P, Ho CM, Montemagno C, Shi W, Qi F, Wu B, Wolinsky L, Wong DT. The Oral Fluid MEMS/NEMS Chip (OFMNC): diagnostic and translational applications. Adv Dent Res 2005 Jun;18(1):3-5.
Axelsson P. Diagnosis and risk prediction of dental caries. 1st ed. Vol 2. Chicago: Quintessence Publishing Ltd.; 2000. 316 p.
Lenander-Lumikari M, Loimaranta V. Saliva and dental caries. Adv Dent Res 2000 Dec;14:40-47.
Tenovuo J. Salivary parameters of relevance for assessing caries activity in individuals and populations. Community Dent Oral Epidemiol 1997 Feb;25(1):82-86.
Edgar WM, Higham SM. Role of saliva in caries model. Adv Dent Res 1995 Nov;9(3):235-238.
Gopinath VK. Saliva as a diagnostic tool for assessment of dental caries. Arch Orofac Sci 2006;1:57-59.
Newburn E. Caries activity tests. Cariology 3rd ed. Chicago: Quintessence Publishing Ltd.; 1989. 389 p.
Louise BM. Assessing caries risk in children. Aus Dent Jour 2000;45(1):10-16.
Nikiforuk G. Understanding dental caries: prevention: basic and clinical aspects. Vol. 2. Basel: Karger; 1985. Chapter 10, Monitoring caries activity; p. 22-241.
van Houte J. Microbiological predictors of caries risk. Adv Dent Res 1993 Aug;7(2):87-96.
Baehni PC, Guggenheim B. Potential of diagnostic microbiology for treatment and prognosis of dental caries and periodontal diseases. Crit Rev Oral Biol Med 1996;7(3):259-277.
Harris No, Garcia-Godoy F. Primary preventive dentistry, 5th ed. New Jersey: Pearson Education; 2004. p. 337-366.
Peter, S. Essentials of preventive and community dentistry. 1st ed. New Delhi; Arya Medi publications; 1999. Chapter 7, Caries activity tests.
Thenisch NL, Bachmann LM, Imfeld T, Leisebach Minder T, Steurer J. Are mutans streptococci detected in preschool children a reliable predictive factor for dental caries risk? A systematic review. Caries Res 2006;40(5):366-374.
Kaufman E, Lamster IB. Analysis of saliva for periodontal diagnosis--a review. J Clin Periodontol 2000 Jul;27(7):453-465.
Mandel, ID. Markers of periodontal disease susceptibility and activity derived from saliva. In: Johnson, NW., editor. Risk markers for oral diseases. Periodontal diseases: Markers of disease susceptibility and activity. Vol. 3. Cambridge University Press; 1991. p. 228-253.
von Troil-Lindén B, Torkko H, Alaluusua S, Jousimies-Somer H, Asikainen S. Salivary levels of suspected periodontal pathogens in relation to periodontal status and treatment. J Dent Res 1995 Nov;74(11):1789-1795.