International Journal of Clinical Pediatric Dentistry

Register      Login

VOLUME 17 , ISSUE 3 ( March, 2024 ) > List of Articles


Comparison between Serum and Salivary Albumin and Calcium Levels in Adolescent Age-group with Dental Caries

Sajan Vaish, Kompal Gautam, Divya Agrawal, A Rizwan Ali, Aparna Choudhary, Akansha Goyal

Keywords : Dental caries, Salivary albumin and calcium, Serum albumin and calcium

Citation Information : Vaish S, Gautam K, Agrawal D, Ali AR, Choudhary A, Goyal A. Comparison between Serum and Salivary Albumin and Calcium Levels in Adolescent Age-group with Dental Caries. Int J Clin Pediatr Dent 2024; 17 (3):328-333.

DOI: 10.5005/jp-journals-10005-2759

License: CC BY-NC 4.0

Published Online: 01-06-2024

Copyright Statement:  Copyright © 2024; The Author(s).


Aim: The aim of our pilot study is to analyze the relationship between dental caries and albumin and calcium levels in serum and saliva in adolescent patients with varying caries experience as determined by their caries progression between the age-group of 9 and 19 years. Materials and methods: A total of 20 subjects were selected based on their level of caries progression and divided into four groups of subjects, five in each as follows: group I—enamel caries, group II—dentinal caries, group III—pulpal caries, and group IV—control group. The saliva and serum were collected under standardized conditions from selected patients and analyzed for the presence of albumin and calcium, and then they were correlated to the same level in serum. The statistical analysis was done using the Chi-squared test. Results: According to the present study, there is an increase in the levels of caries with a decrease in the levels of salivary albumin and calcium. Serum albumin and calcium levels were also found to be decreased in caries-prone individuals; hence, a significant correlation between serum and salivary albumin and calcium levels was found. Conclusion: According to a review of the literature, we found an inverse relationship between the levels of albumin and calcium in serum and saliva with dental caries patients. So, it confirms the importance of albumin and calcium levels in inhibiting carrier progression. So it may be used as a biochemical indicator to evaluate the susceptibility of caries.

PDF Share
  1. Hegde MN, Kumari S, Moany A, et al. Correlation between total antioxidant level and dental caries in adult patients – an in vivo study. Res J Pharm Biol Chem Sci 2011;2(4):864–870.
  2. Battino M, Ferreiro MS, Gallardo I, et al. The antioxidant capacity of saliva. J Clin Periodontol 2002;29(3):189–194. DOI: 10.1034/j.1600-051x.2002.290301x.x
  3. Dowd FJ. Saliva and dental caries. Dent Clin North Am 1999;43(4):579–597. PMID: 10553245.
  4. Hegde MN, Bhat R, Punja A, et al. Correlation between dental caries and salivary albumin in adult Indian population–an in vivo study. Br J Med Med Res 2014;4(25):4238–4244. DOI: 10.9734/BJMMR/2014/9296
  5. Pandey P, Reddy NV, Rao V, et al. Estimation of salivary flow rate, pH, buffer capacity, calcium, total protein content and total antioxidant capacity in relation to dental caries severity, age and gender. Contemp Clin Dent 2015;6(Suppl 1):S65–S71. DOI: 10.4103/0976-237X.152943
  6. Hegde MN, Tahiliani D, Shetty S, et al. Salivary alkaline phosphatase and calcium in caries-active type II diabetes mellitus patients: an in vivo study. Contemp Clin Dent 2014;5(4):440–444. DOI: 10.4103/0976-237X.142805
  7. Levine M. Susceptibility to dental caries and the salivary proline-rich proteins. Int J Dent 2011;2011:953412. DOI: 10.1155/2011/953412
  8. van der Linden AH, Booij M, ten Bosch JJ, et al. Albumin interaction with caries-like lesions in bovine enamel. Caries Res 1989;23(6):393–398. DOI: 10.1159/000261216
  9. Tulunoglu O, Demirtas S, Tulunoglu I. Total antioxidant levels of saliva in children related to caries, age, and gender. Int J Paediatr Dent 2006;16(3):186–191. DOI: 10.1111/j.1365-263X.2006.00733.x
  10. Stookey GK. The effect of saliva on dental caries. J Am Dent Assoc 2008;139:272–285. DOI: 10.14219/jada.archive.2008.0347
  11. Darling AI. Studies on the early lesion of enamel caries. Br Dent J 1956;101:289–297, 329–341.
  12. Silverstone LM, Johnson NW, Hardie JM, et al. Enamel caries. In: Dental caries. London: Palgrave; 1981. DOI: 10.1007/978-1-349-16547-6_6.
  13. Kaur A, Kwatra KS, Kamboj P. Evaluation of non-microbial salivary caries activity parameters and salivary biochemical indicators in predicting dental caries. J Indian Soc Pedod Prev Dent 2012;30(3):212–217. DOI: 10.4103/0970-4388.105013.
  14. Sheetal A, Hiremath VK, Patil AG, et al. Malnutrition and its oral outcome: a review. J Clin Diagn Res 2013;7(1):178–180. DOI: 10.7860/JCDR/2012/5104.2702
  15. Psoter WJ, Reid BC, Katz RV. Malnutrition and dental caries: a review of the literature. Caries Res 2005;39(6):441–447. DOI: 10.1159/000088178
  16. Robinson C, Shore RC, Bonass WA, et al. Identification of human serum albumin in human caries lesions of enamel the role of putative inhibitors of remineralisation. Caries Res 1998;32(3):193–199. DOI: 10.1159/000016452
  17. Boyd JD, Drain CL, Stearns G. Metabolic studies of children with dental caries. J Biol Chem 1993;103(2):327–337. DOI: 10.1016/S0021-9258(18)75811-0
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.