Background: Tobacco use amongst adolescents causes significant health problems affecting almost all organs and has a significant effect on normal growth and development. Smoker adolescents are also more prone to oral health problems than nonsmokers. Pediatric dentists can play a significant role in providing tobacco cessation counseling to adolescents. Aim: To assess the knowledge (K), perceptions (PR), training, and practices (PE) of pediatric dentists related to the provision of tobacco cessation interventions. Materials and methods: A cross-sectional online survey with convenience sampling was planned to assess the K, PR, training, and PE of pediatric dentists across the globe in dealing with tobacco menace amongst adolescents. The survey was done through a self-administered questionnaire in the form of an online Google Form. The study population consisted of pediatric dentists attending the International Academy of Pediatric Dentistry (IAPD) virtual conference 2021. Results: A total of 1,564 participants were targeted and 235 answered the survey with a response rate of 15.02%. Attending tobacco cessation intervention (p ≤ 0.001) and training in postgraduation on tobacco cessation (p ≤ 0.002) showed significant association with favorable practice scores. However, in the PR domain age in years (p ≤ 0.043), country of residence (continent, p ≤ 0.001) was found to be significantly associated with attending tobacco cessation intervention (p < 0.001) and training in postgraduation (p < 0.001). Conclusion: The results of the study emphasize the need for recommendations for educating pediatric dentists by the inclusion of tobacco cessation interventions in the core curriculum, continuing dental education programs, and promoting professional responsibility to help achieve tobacco-free youth all across the globe.