Citation Information :
Talekar AL, Musale PK, Kothare SS. Dental Caries and Dental Anomalies in Children Undergoing Chemotherapy for Malignant Diseases. Int J Clin Pediatr Dent 2022; 15 (4):428-432.
Purpose: The study aims to evaluate the prevalence of dental caries and anomalies in pediatric patients undergoing chemotherapy or those who have completed chemotherapy. Methods: A total of 250 pediatric patients within the age group of 6 months to 17 years, either admitted to hospitals for chemotherapy or on follow-up, were included as a part of the study. Complete oral examination inclusive of the diet history, oral hygiene methods, past dental history, the decayed, missing, and filled teeth (DMFT), def score, and any dental anomaly was diagnosed clinically and radiographically using an orthopantomogram. The samples were further categorized under type of malignancies and duration of chemotherapeutic drug usage groups (from 6 months to 10 years and more than 10 years) to establish a correlation of these variables with the prevalence of dental caries and dental anomalies. Results: Among all patients, 108 (43.2%) had completed the treatment (chemotherapy), while 142 (56.8%) were undergoing the treatment. Forty-three (17.2%) patients showed positive findings for dental anomalies. Conclusion: The present study confirms the strong positive correlation between long-term exposure to chemotherapeutic agents and the prevalence of dental anomalies and dental caries in children.
Barr R, Riberio R, Agarwal B, et al. Pedriatic oncology in countries with limited resources. In: Pizzo PA, Poplak DG, editors. Principles and Practice of Paediatric Oncology. 5th ed. Philadelphia: Lippincott Williams and Wilkins; 2006. p. 1605–1617.
Stiller CA, Parkin DM. Geographic variations in the incidence of childhood cancer. Br Med Bull 1996;52(4):682–703. DOI: 10.1093/oxfordjournals.bmb.a011577
Parkin DM, Stiller CA, Draper GJ, et al. The international incidence of childhood cancer. Int J Cancer 1988;42(4):511–520. DOI: 10.1002/ijc.2910420408
Arora RS, Eden T, Kapoor G. Epidemiology of childhood cancer in India: review article. Indian J Cancer 2009;49(4):264–273. DOI: 10.4103/0019-509X.55546
Abu Bashar MD, Thakur JS. Incidence and pattern of childhood cancers in India: findings from population-based cancer registries. Indian J Med Paediatr Oncol 2017;38(2):240–241. DOI: 10.4103/ijmpo.ijmpo_163_16
Parkin DM, Whelan SL, Ferlay J, et al. Cancer Incidence in Five Continents. Vol I to VIII. IARC Cancer Base No. 7, Lyon; 2005.
Brennan MT, Woo SB, Lockhart PB. Dental treatment planning and management in the patient who has cancer. Dent Clin North Am 2008;52(1):19–37. DOI: 10.1016/j.cden.2007.10.003
Sonis AL, Tarbell N, Valachovic RW, et al. Dentofacial development in long-term survivors of acute lymphoblastic leukemia: a comparison of three treatment modalities. Cancer 1990;66(12):2645–2652. DOI: 10.1002/1097-0142(19901215)66:12<2645::aid-cncr2820661230>3.0.co;2-s
Cigden CE, Gunes AM. Caries experience of leukemic children during intensive course of chemotherapy. J Clin Padiatr Dent 2008;32(2):155–158.
Welbury RR, Craft AW, Murray JJ, et al. Dental health of survivors of malignant disease. Arch Dis Child 1984;59(12):1186–1187. DOI: 10.1136/adc.59.12.1186
Suri L, Gagari E, Vastardis H. Delayed tooth eruption: pathogenesis, diagnosis and treatment. A literature review. Am J Orthod Dentofacial Orthop 2004;126(4):432–445. DOI: 10.1016/j.ajodo.2003.10.031
Maguire A, Craft AW, Evans RG, et al. The long-term effects of treatment on dental condition of surviving malignant disease. Cancer 1987;60(10):2570–2575. DOI: 10.1002/1097-0142(19871115)60:10<2570::aid-cncr2820601037>3.0.co;2-q
Purdell-Lewis DJ, Stalman MS, Leeuw JA, et al. Long term results of chemotherapy on the developing dentition: caries risk and developmental aspects. Community Dent Oral Epidemiol 1988;16(2):68–71. DOI: 10.1111/j.1600-0528.1988.tb01845.x
Stephen A, Martin EJ. Oral complications in pediatric oncology patients. Pediatr Dent 1991;13(5):289–295.
Hong CHL, Napeñas JJ, Hodgson BD, et al. A systematic review of dental disease in patients undergoing cancer therapy. Supportive Care Cancer 2010;18(8):1007–1021. DOI: 10.1007/s00520-010-0873-2
Nunn JH, Welbury RR, Gordon PH, et al. Dental caries and dental anomalies in children treated by chemotherapy for malignant disease: a study in the north of England. Int J Paed Dent 1991;1(3):131–135. DOI: 10.1111/j.1365-263x.1991.tb00331.x
Cho SY, Cheng AC, Cheng MCK. Oral care for children with leukemia. Hong Kong Med J 2000;6(2):203–208.
Franch AM, Esteve EG, Perez MS. Oral manifestations and dental management of patient with leukocyte alterations. J Clin Exp Dent 2011;3(1):e53–e59. DOI: 10.4317/jced.3.e53
Walsh LJ. Clinical assessment and management of the oral environment in the oncology patient. Aust Dent J 2010;55(s1):66–77. DOI: 10.1111/j.1834-7819.2010.01201.x
Dahllof G, Rozell B, Forsberg CM, et al. Histologic changes in dental morphology induced by high dose chemotherapy and total body irradiation. Oral Surg Oral Med Oral Pathol Oral Radiol 1994;77(1):56–60. DOI: 10.1016/s0030-4220(06)80107-6
Jelena R, Andjelka R, Vladimir A. Increased prevalence of minor anomalies in children with hematological malignancies. Med Pediatr Oncol 2002;38(2):128–130. DOI: 10.1002/mpo.1288
Nasim VS, Shetty YR, Hegde AM. Dental health status in children with acute lymphoblastic leukemia. J Clin Pediatr Dent 2007;31(3):210–221. DOI: 10.1002/mpo.1288.abs
Sonis ST. Oral mucositis in cancer therapy. J Support Oncol 2004;2(6):003–008.
American Academy of Pediatric Dentistry. Guideline on dental management of pediatric patients receiving chemotherapy, hematopoietic cell transplantation, and/or radiation therapy. Pediatr Dent 2013;35(5):E185–E193.
Shilpa G, Gokhale N, Mallineni SK, et al. Prevalence of dental anomalies in deciduous dentition and its association with succedaneous dentition: a cross-sectional study of 4180 South Indian children. J Indian Soc Pedod Prev Dent 2017;35(1):56–62. DOI: 10.4103/0970-4388.199228
Avsar A, Elli N, Darka O, et al. Long term effects of chemotherapy on caries formation, dental development and salivary factors in childhood cancer survivors. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007;104(6):781–789. DOI: 10.1016/j.tripleo.2007.02.029
Paivi H, Satu A, Ulla MS, et al. Agenesis and microdontia of permanent teeth as late adverse effects after stem cell transplantation in young children. Cancer 2005;103(1):181–190. DOI: 10.1002/cncr.20762
Remmers D, Bokkerink JPM, Katsaros C. Microdontia after chemotherapy in a child treated for neuroblastoma. Orthod Craniofac Res 2006;9(4):206–210. DOI: 10.1111/j.1601-6343.2006.00374.x
Krasuska-Sławińska E, Brożyna A, Dembowska-Bagińska B, et al. Antineoplastic chemotherapy and congenital tooth abnormalities in children and adolescents. Contemp Oncol (Pozn) 2016;20(5);394–401. DOI: 10.5114/wo.2016.64602
Alpaslan G, Alpaslan C, Gogen H, et al. Disturbances in oral and dental structures in patients with pediatric lymphoma after chemotherapy: a preliminary report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1999;87(3):317–321. DOI: 10.1016/s1079-2104(99)70215-5
Proc P, Szczepańska J, Skiba A, et al. Dental anomalies as late adverse effect among young children treated for cancer. Can Res Treat 2016;48(2):658–667. DOI: 10.4143/crt.2015.193