Langerhans’ cell histiocytosis (LCH) is a rare disease of the reticuloendothelial system in which there are abnormal proliferation and accumulation of histiocytes, abnormal cells deriving from bone marrow that can migrate from the skin to the lymph nodes. Langerhans’ cell histiocytosis has three variants: unifocal (eosinophilic granuloma), multifocal unisystem (Hand–Schuller–Christian triad), and multifocal multisystem (Letterer–Siwe disease). We present a case of oral lesions associated with LCH in a young male aged 15 years. The history, radiological appearance, histopathology, and treatment options of the patient are discussed.
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