Aim and objective: To compare and evaluate the retention along with antibacterial efficacy of colored compomer and glass hybrid bulk fill glass ionomer restorative material as a conservative adhesive restoration in children of age 6–12 years. Materials and methods: Sixty children were selected fulfilling the inclusion and exclusion criteria falling in the age group of 6–12 years with mixed dentition and two groups were formed: group I—colored compomer and group II—glass hybrid bulk fill material. Initially, oral prophylaxis was carried out and baseline collection of saliva was completed. Then, the restorative treatment was completed. Retention of the material and antibacterial count [colony-forming units (CFU)/mL of saliva] was estimated at 1, 3, and 6 months after the restorative procedure. Results: It was seen that retention rate with glass hybrid bulk fill group was 100%, whereas with colored compomer group it was 90% at end of 6 months. Although good antibacterial activity was shown by both the group at 1, 3, and 6 months follow-up but statistically significant drop was seen in the glass hybrid bulk fill group at 3-month intervals than the colored compomer group with a p value of 0.0001 (p < 0.05). Conclusion: Among both the materials, glass hybrid bulk fill restorative material showed good retention compared to Colored compomer material but it was not statistically very significant. Also, both the materials have shown good antimicrobial activity at 1, 3, and 6 months follow-up.