International Journal of Clinical Pediatric Dentistry

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VOLUME 13 , ISSUE 6 ( November-December, 2020 ) > List of Articles

CASE REPORT

A Rare Case of Osteoclast-poor Osteopetrosis (RANKL Mutation) with Recurrent Osteomyelitis of Mandible: A Case Report

Ankit Sharma, Snehal N Ingole, Mohan D Deshpande, Noaman Kazi, Deepashree Meshram, Pallavi Ranadive

Keywords : Osteoclast, Osteoclast-poor, Osteomyelitis, Osteopetrosis

Citation Information : Sharma A, Ingole SN, Deshpande MD, Kazi N, Meshram D, Ranadive P. A Rare Case of Osteoclast-poor Osteopetrosis (RANKL Mutation) with Recurrent Osteomyelitis of Mandible: A Case Report. Int J Clin Pediatr Dent 2020; 13 (6):717-721.

DOI: 10.5005/jp-journals-10005-1835

License: CC BY-NC 4.0

Published Online: 31-03-2021

Copyright Statement:  Copyright © 2020; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Osteopetrosis (OP) is a group of rare genetic bone disorders. Osteoclast-poor form of osteopetrosis is much rarer in humans and represents a small percentage of the total cases of autosomal recessive osteopetrosis presenting with impaired bone remodeling due to defective osteoclastic activity and is characterized by distinctive increase in bone density and high bone fragility. Reduction in marrow spaces with decreased vasculature to the bone owing to increased bone mass makes the bones vulnerable for varied infections resulting in osteomyelitis. This case report discusses challenges in management of recalcitrant osteomyelitis of mandible developed as a complication in an 8-year-old girl child identified with rare, dual heterozygous mutations in RANKL (TNFSF11) gene and COL5A1 gene with uncertain significance responsible for osteoclast-poor osteopetrosis and Classic Ehlers-Danlos, respectively.


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