International Journal of Clinical Pediatric Dentistry

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VOLUME 13 , ISSUE 4 ( July-August, 2020 ) > List of Articles

Original Article

Pulp Revascularization/Revitalization of Bilateral Upper Necrotic Immature Permanent Central Incisors with Blood Clot vs Platelet-rich Fibrin Scaffolds—A Split-mouth Double-blind Randomized Controlled Trial

Hazim Mohamed Rizk, Mohamed Sherif Salah AL-Deen, Asmaa Aly Emam

Citation Information : Rizk HM, AL-Deen MS, Emam AA. Pulp Revascularization/Revitalization of Bilateral Upper Necrotic Immature Permanent Central Incisors with Blood Clot vs Platelet-rich Fibrin Scaffolds—A Split-mouth Double-blind Randomized Controlled Trial. Int J Clin Pediatr Dent 2020; 13 (4):337-343.

DOI: 10.5005/jp-journals-10005-1788

License: CC BY-NC 4.0

Published Online: 09-10-2020

Copyright Statement:  Copyright © 2020; The Author(s).


Abstract

Objectives: Clinical and radiographic evaluation of the regeneration of bilateral necrotic upper permanent central incisors with open apex using blood clot (BC) and platelet-rich fibrin (PRF) scaffolds. Trial design: Split-mouth double-blind parallel arm randomized controlled clinical trial. Materials and methods: Randomization and blinding: The study started with 15 patients with bilateral necrotic upper permanent central incisors with open apex. Computer-generated tables were used to allocate treatments. The two maxillary central incisors were randomly assigned to either the control (BC scaffold) or the examined (PRF scaffold) groups. Participants: Thirteen patients aged 8–14 years fulfilled the study requirements. Follow-up was performed for 3, 6, 9, and 12 months. Standardized radiographs were collected each 3 months, and difference in measurements was calculated using Image J software. Primary outcomes measured were sinus/fistula formation, pain complaint, mobility grade, and swelling presence/absence. Radiographic: Root length elongation and increase in root thickness. Secondary outcomes were sensibility test and crown color change. Radiographic: Change in bone density and apical diameter. Radiographs that were standardized used during the follow-up time, and occurred changes were calculated using Image J software. Results: One patient was lost during follow-up; therefore, 24 treated teeth were analyzed, they showed 100% success rate. Platelet-rich fibrin teeth displayed a statistically significant growth in radiographic root length and width, increased periapical bone density, and a reduction in apical diameter when compared with BC. At the end of the follow-up period, all treated teeth were negative to sensibility test. Blood clot displayed greater crown discoloration in comparison to PRF group. Conclusion: For teeth with open apex and necrotic pulp, revascularization using PRF is an appropriate substitute to BC.


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