Dental Management of Neurofibromatosis Type 1: A Case Report and Literature Review
Fabienne Wotjiuk, Isabelle Hyon, Sylvie Dajean-Trutaud, Zahi Badran, Tony Prud homme
Citation Information :
Wotjiuk F, Hyon I, Dajean-Trutaud S, Badran Z, Prud homme T. Dental Management of Neurofibromatosis Type 1: A Case Report and Literature Review. Int J Clin Pediatr Dent 2019; 12 (6):577-581.
Neurofibromatosis type 1 (NF1) is a clinically heterogeneous neurocutaneous genetic disorder that manifests in the form of coffee-milk spots on the skin, Lish nodules, lentigines on the underarms and on the inguinal region, and neurofibromas. Orofacial manifestations of NF1 are common. Through a review of the literature, bone lesions, orthodontic and dental abnormalities, periodontal manifestations, and caries related to NF1 will be explored. In this study, we present a clinical case of a patient with neurofibroma in the oral cavity and infraocclusion of primary molars, as well as his dental management.
Friedrich RE, Giese M, et al. Jaw malformations plus displacement and numerical aberrations of teeth in neurofibromatosis type I: a descriptive analysis of 48 patients based on panoramic radiographs and oral findings. J Cranio-Maxillo-fac Surg Off Publ Eur Assoc Cranio-Maxillo-fac Surg 2003 Feb;31(1):1–9. DOI: 10.1016/S1010-5182(02)00160-9.
Cunha KSG, Barboza EP, et al. Neurofibromatosis type I with periodontal manifestation. A case report and literature review. Br Dent J 2004 Apr 24;196(8):457–460. DOI: 10.1038/sj.bdj.4811175.
Visnapuu V, Peltonen S, et al. Radiographic findings in the jaws of patients with neurofibromatosis 1. J Oral Maxillofac Surg Off J Am Assoc Oral Maxillofac Surg 2012 Jun;70(6):1351–1357. DOI: 10.1016/j.joms.2011.06.204.
Javed F, Ramalingam S, et al. Oral manifestations in patients with neurofibromatosis type I: a comprehensive literature review. Crit Rev Oncol Hematol 2014 Aug;91(2):123–129. DOI: 10.1016/j.critrevonc.2014.02.007.
Geist JR, Gander DL, et al. Oral manifestations of neurofibromatosis types I and II. Oral Surg Oral Med Oral Pathol 1992 Mar;73(3):376–382. DOI: 10.1016/0030-4220(92)90139-H.
D'Ambrosio JA, Langlais RP, et al. Jaw and skull changes in neurofibromatosis. Oral Surg Oral Med Oral Pathol 1988 Sep;66(3): 391–396. DOI: 10.1016/0030-4220(88)90252-6.
Shapiro SD, Abramovitch K, et al. Neurofibromatosis: oral and radiographic manifestations. Oral Surg Oral Med Oral Pathol 1984 Oct;58(4):493–498. DOI: 10.1016/0030-4220(84)90350-5.
Bardellini E, Amadori F, et al. Oral findings in 50 children with neurofibromatosis type I. A case control study. Eur J Paediatr. Dent Off J Eur Acad Paediatr Dent 2011 Dec;12(4):256–260.
Friedrich RE, Giese M, et al. Size of tooth crowns and position of teeth concerning the extension of facial plexiform neurofibroma in patients with neurofibromatosis type I. Anticancer Res 2012 May;32(5):2207–2214.
Lammert M, Friedrich RE, et al. Early primary tooth eruption in neurofibromatosis 1 individuals. Eur J Oral Sci 2007 Oct;115(5): 425–426. DOI: 10.1111/j.1600-0722.2007.00474.x.
Jääsaari P, Visnapuu V, et al. Dental age in patients with neurofibromatosis 1. Eur J Oral Sci 2012 Dec;120(6):549–552. DOI: 10.1111/j.1600-0722.2012.01000.x.
Visnapuu V, Peltonen S, et al. Periapical cemental dysplasia is common in women with NF1. Eur J Med Genet 2007 Aug;50(4):274–280. DOI: 10.1016/j.ejmg.2007.04.001.
Bardellini E, Tonni I, et al. Occlusal traits in children with neurofibromatosis type I. Orthod Craniofac Res 2016 Feb;19(1):46–53. DOI: 10.1111/ocr.12108.
Tucker T, Birch P, et al. Increased dental caries in people with neurofibromatosis 1. Clin Genet 2007 Dec;72(6):524–527. DOI: 10.1111/j.1399-0004.2007.00886.x.
Tsang ES, Birch P, et al. Prevalence of dental caries in children with neurofibromatosis 1. Clin Oral Investig 2010 Aug;14(4):479–480. DOI: 10.1007/s00784-009-0361-6, author reply 480.
Lammert M, Friedman JM, et al. Vitamin D deficiency associated with number of neurofibromas in neurofibromatosis 1. J Med Genet 2006 Oct;43(10):810–813. DOI: 10.1136/jmg.2006.041095.
Visnapuu V, Pienihäkkinen K, et al. Neurofibromatosis 1 and dental caries. Clin Oral Investig 2011 Feb;15(1):119–121. DOI: 10.1007/s00784-009-0341-x.