International Journal of Clinical Pediatric Dentistry

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VOLUME 12 , ISSUE 4 ( July-August, 2019 ) > List of Articles

RESEARCH ARTICLE

Comparative Evaluation of BMI, Dental Age, Salivary Alkaline Phosphatase Levels, and Oral Health Status in Children with β Thalassemia Major

Sandipamu T Rani, Eddula R Reddy, Merum Kiranmai, Srujana P Mudusu, Saraswathi Srikanth, Suman Jain

Keywords : β thalassemia major, Body mass index, Intervention urgency index, Oral health status, Salivary alkaline phosphatase

Citation Information : Rani ST, Reddy ER, Kiranmai M, Mudusu SP, Srikanth S, Jain S. Comparative Evaluation of BMI, Dental Age, Salivary Alkaline Phosphatase Levels, and Oral Health Status in Children with β Thalassemia Major. Int J Clin Pediatr Dent 2019; 12 (4):303-306.

DOI: 10.5005/jp-journals-10005-1641

License: CC BY-NC 4.0

Published Online: 00-08-2019

Copyright Statement:  Copyright © 2019; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Purpose: Thalassemia poses clear systemic and oral health problems. Clinicians must be aware of various dental treatment needs in these patients. This study was undertaken to assess body mass index (BMI), dental age, salivary alkaline phosphatase levels, malocclusion, and treatment needs in children with β thalassemia major. Materials and methods: A total of 100 children within the age group of 2–15 years (50 thalassemic and 50 healthy controls) were included. Dental age, oral health status, malocclusion, and intervention urgency index was recorded. Unstimulated whole saliva samples were collected to assess the salivary alkaline phosphatase levels. The recorded data were statistically analyzed. Results: A significantly greater number of thalassemia children were found to be in the underweight category. A significantly high OHI-S scores and low gingival index scores were observed in thalassemia children. Salivary alkaline phosphatase levels were significantly low in thalassemia children compared to the control group. Intervention urgency index scores were significantly high in thalassemia group of children. Conclusion: Thalassemia children had low BMI, gingival index scores, salivary alkaline phosphatase levels and higher prevalence of malocclusion, and high OHI-S index scores compared to the healthy control group. Intervention urgency index scores revealed greater dental treatment needs in children with thalassemia.


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  1. Singh J, Singh N, et al. Dental And Periodontal Health Status of Beta Thalassemia Major and Sickle Cell Anaemic Patients: A Comparative Study. 2013;5(5):53–58.
  2. Yaish HM. Thalassemia. http://www.Emedicine.com/PED/topic 2229.htm. Accessed 6th August. 2007.
  3. Verma IC, Choudary VP, et al. Prevention of Thalassemia. A necessity in India. Indian J Pediatr 1992;59:649–654. DOI: 10.1007/BF02859390.
  4. Rajajee KTSS, Jampanapalli SR, et al. Prevalence of Dental Caries, Oral Hygiene Status, Malocclusion Status and Dental Treatment Needs in Thalassemic Children – A Cross Sectional Study. Sch Acad J Biosci 2017;5(1):41–46.
  5. Manglani M, Lokeshwar MR, et al. ‘NESROFT’ – an effective screening test for β thalassemia trait. Indian Pediatr 1997;34:703–708.
  6. Haddad A, Tyan P, et al. β thalassemia Intermedia: A Bird's – eye view. Turk J Hematol 2014;31(1):5–16. DOI: 10.4274/Tjh.2014.0032.
  7. Hoffbrand AV, Lewis SM, et al. Post Graduate Hematology, 4th ed., Oxford: Butterworth Heinemann; 1999.
  8. Pirinccioglu AG, Akpolat V, et al. Bone density in children with beta thalassemia major in Diyarbakir. Bone 2011;49:819–823. DOI: 10.1016/j.bone.2011.07.014.
  9. Aldallal S, AlKathemi M. Orodental Considerations in Thalassemia Patients. J of Haematol and Blood Disord 2016;2(2):205.
  10. De Almeida PDV, Gregio AMT, et al. Saliva composition and functions: a Comprehensive Review. J Contemp Dent Pract 2008;9(3):72–80. DOI: 10.5005/jcdp-9-3-72.
  11. WHO. Oral health Surveys: Basic Methods. 5th ed. Annexure 2. p. 85.
  12. Cooley T, Lee P. A series of cases of splenomegaly in children with anaemia and peculiar bone changes. Trans Am Pediatr 1925;37:29–30.
  13. Dhote V, Thosar N, et al. Evaluaiton of oral hygiene status and salivary biochemistry of patients with Thalassemia major: a clinical study. IOSR-JDMS J Med Dent Sci 2015;14(12):98–102.
  14. Laor E, Garfunkel A, et al. Prevalence of Orofacial complications in Iranian patients with β thalassemia major. Iranian J Publ Health 2007;36:43–46.
  15. Al- Wadhani AM, Taani DQ, et al. Dental diseases in subjects with beta thalassemia major. Community Dent Oral Epidemiol 2002;30(6): 418–422. DOI: 10.1034/j.1600-0528.2002.00012.x.
  16. Qureshi A, Chaudhry S, et al. Is oral health status of children with β thlalassemia worse than that of their normal counterparts? J Khyber Colle Dent 2010;1(1):4–7.
  17. Arora M, Nayeemuddin SM, et al. Growth impairment and Dental caries in Thalassemia Major Patients. Indian J Clin Anat Physiol 2014;1:15–20.
  18. Kaur N, Hiremath SS. Dental caries and gingival status of 3–14 year old beta thalassemia major patients attending paediatric OPD of Vanivilas hospital. Banglore Arch Oral Sci Res 2012;2:67–70.
  19. Bucci E, Muzio LO, et al. β-thalassemiated implicazioni odontostomatologiche. Minerva Stomatologica 1990;39:35–38.
  20. Hattab FN, Hazza'a AM, et al. Caries risk in patients with thalassemia major. Int Dent J 2001;51:751–765.
  21. Helm S, Petrsen PE. Causal relation between malocclusion and periodontal health. Acta Odontol Scand 1989;47:223–238. DOI: 10.3109/00016358909007705.
  22. Schlott WJ. Occlusion and dentl adisease. Dental Today 1999;18:72–77.
  23. Mehdizadhe M, Zamani G. Orodental complications in patients with Thalassemia. J Dent Res 2008;5(1):17–20.
  24. Siamopoulou-Mavridou A, Mavridis A, et al. Flow rate and chemistry of parotid saliva related to dental caries and gingivitis in patients with thalassemia major. Int J Clin Pediatr Dent 1992;2:93–97. DOI: 10.1111/j.1365-263X.1992.tb00016.x.
  25. Madhok S, Madhok S. Dental considerations in Thalassemic patients. IOSR-JDMS 2014;13:57–62. DOI: 10.9790/0853-13645762.
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