International Journal of Clinical Pediatric Dentistry

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VOLUME 11 , ISSUE 6 ( November-December, 2018 ) > List of Articles


Efficacy of Myristica fragrans and Terminalia chebula as Pulpotomy Agents in Primary Teeth: A Clinical Study

Shikha Mali, Ankit Gautam, Babita Niranjan

Keywords : Formocresol, Myristica fragrans, Pulpotomy, Primary teeth, Terminalia chebula

Citation Information : Mali S, Gautam A, Niranjan B. Efficacy of Myristica fragrans and Terminalia chebula as Pulpotomy Agents in Primary Teeth: A Clinical Study. Int J Clin Pediatr Dent 2018; 11 (6):505-509.

DOI: 10.5005/jp-journals-10005-1565

License: CC BY-NC 4.0

Published Online: 01-04-2012

Copyright Statement:  Copyright © 2018; The Author(s).


Background: Pulpotomy is the treatment for cariously exposed vital primary molars. Using Formocresol as a pulpotomy agent is been in controversy, which has triggered the search for better alternatives. The product like ‘Myristica fragrans (MF)–Nutmeg gel, Terminalia chebula (TC)–Myrobolan gel is gaining popularity as herbal pulpotomy agents. Aim: To evaluate and compare clinical and radiographical success of herbal gels Myristica fragrans (MF)–Nutmeg, and Terminalia chebula (TC)–Myrobolan as pulpotomy medicaments in primary teeth. Materials and methods: Twenty participants (n = 20), each with at least two primary molars requiring pulpotomy, were selected and divided into two test groups. In 10 children Terminalia chebula gel was placed in one side and Formocresol on another side. Rest 10 children were treated with Myristica fragrans gel on one side and another side with formocresol. The treated teeth selected for clinical and radiographic evaluation were monitored periodically for 3, 6 and 12 months. Results: With the follow-up of 12 months there was no significant difference in efficacy of all three pulpotomy medicaments, i.e. Nutmeg, Myrobolan, and Formocresol, respectively was found Conclusion: Herbal gels have a promising role in dentistry having the proper knowledge, and their effects on teeth would prove them as a successful dental therapeutic agent.

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  1. Seale NS, Coll JA. Vital pulp therapy for the primary dentition. Gen Dent 2010;58:194.200.
  2. Thilla SV, Rubin MI, Balaji L, et al. In vitro evaluation of five different herbal extracts as an antimicrobial endodontic irrigant using real time quantitative polymerase chain reaction. J Cons Dent 2013;16(2):167-170.
  3. Jaiswal P, Kumar P, Singh VK, et al. Biological effects of Myristica fragrans. Annual Rev Biomed Sci. 2009;11: 21-29.
  4. Qiu Q, Zhang G, Sun X, Liu X. Study on chemical constituents of the essential oil from Myristica fragrans Houtt by supercritical fluid extraction and steam distillation. J Chinese Med Mater 2004;27(11):823-826.
  5. Chung JY, Choo JH, Lee MH, et al. Anticariogenic activity of macelignan isolated from Myristica fragrans (nutmeg) against Streptococcus mutans. Phytomedicine 2006;13(4): 261-266.
  6. Cheng HY, Lin TC, Yu KH, et al. Antioxidant and free radical screening activities of Terminalia chebula. Biol Pharm Bull 2003;26(9):1331-1335.
  7. Malekzadeh F, Ehsanifar H, Shahamat M, et al. Antibacteria activity of black myrobalan (Terminalia chebula Retz) against Helicobactor pyroli. Int. Int J Antimicrob Agents 2001;18(1): 85-88.
  8. Suguna L, Singh S, Sivakumar P, et al. Influence of Terminalia chebula on dermal wound healing of rats. Phytother Res. 2002;16(3):227-231.
  9. Chatopadhyay RR, Bhattacharyya SK, Medda C, Chanda S, Datta S,.Pal NK. Antibacterial activity of black myrobalan (Fruit of Terminalia chebula Retz) against uropathogen Escherichia coli. Phcog Mag 2007;11:212-215.
  10. Tandon S, Gopinath VK. Treatment Modalities. In: Textbook of Pedodontics (1st ed) 2003;342.
  11. Waterhouse PJ, Nunn JH, Whitworth JM, et al. Primary molar pulp therapy – Histological evaluation of failure. Int J Paediatr Dent 2000;10:313-321.
  12. Lewis B. Formaldehyde in dentistry: a review for the millennium. J Clin Pediatr Dent 1998;22:167-177.
  13. Sugun L, Sing S, Sivakuma P, et al. Influence of Terminalia chebula on dermal wound healing in rats. Phytotherapy Res. 2002;16(3):227-231.
  14. Valero M, Salmerón MC. Antibacterial activity of 11 essential oils against Bacillus cereus in tantalized carrot broth. Int J Food Microbiol 2003;85:73-81.
  15. Orabi KY, Mossa JS, el-Feraly FS. Isolation and characterization of two antimicrobial agents from mace (Myristica fragrans). J Nat Prod 1991;54:856-859.
  16. Zaleha S, Shuhairi NN, Yap NMF, et al. Antibacterial activity of Myristica fragrans against oral pathogens. J Evidence-Based Complementary Altern Med 2012;1-7.
  17. Tezuka Y, Irikawa S, Kaneko T. Screening of Chinese herbal drug extracts for inhibitory activity on nitric oxide production and identification of an active compound of Zanthoxylum bungeanum. J Ethnopharmacol 2001;77:209-217.
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