International Journal of Clinical Pediatric Dentistry

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VOLUME 10 , ISSUE 2 ( April-June, 2017 ) > List of Articles

ORIGINAL ARTICLE

Assessment of Vitamin B12 and Its Correlation with Dental Caries and Gingival Diseases in 10- to 14-year-old Children: A Cross-sectional Study

Laresh Mistry, Neha S Dhariwal, Andleeb Majeed

Citation Information : Mistry L, Dhariwal NS, Majeed A. Assessment of Vitamin B12 and Its Correlation with Dental Caries and Gingival Diseases in 10- to 14-year-old Children: A Cross-sectional Study. Int J Clin Pediatr Dent 2017; 10 (2):142-146.

DOI: 10.5005/jp-journals-10005-1424

License: CC BY-NC 4.0

Published Online: 01-06-2017

Copyright Statement:  Copyright © 2017; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Aim

To assess the level of vitamin B12 and correlate it with dental caries [decayed, missing, and filled permanent teeth (DMFT) score] and gingival diseases [plaque index (PI) and gingival index (GI)].

Design

Healthy children according to the inclusion criteria were selected by the computerized randomization method from a school to assess the vitamin B12 levels using Centaur/Versace machine.

Materials and methods

Blood samples were collected to assess vitamin B12 levels using automated analyzer. Oral examination was done by a single calibrated dentist. A thorough oral examination was carried out and the DMFT, PI, and GI scores of all the children were recorded and assessed. Data were analyzed using Karl Pearson's correlation test.

Results

Vitamin B12 levels were deficient in 64% of the children. In boys, vitamin B12 deficiency was found in about 76.2%, whereas, in girls it was 57.1%, which was not statistically significant. The vitamin B12 deficient children showed a significantly high DMFT scores than the children with normal vitamin B12 levels. The Pearson's correlation was –0.614 for DMFT, PI value –0.663, and GI value of –0.477. The negative correlation stated that there was a reverse relation between these indices and vitamin B12.

Conclusion

In children with systemic vitamin B12 deficiency, there is increased dental caries prevalence and associated gingival problems.

How to cite this article

Hugar SM, Dhariwal NS, Majeed A, Badakar C, Gokhale N, Mistry L. Assessment of Vitamin B12 and Its Correlation with Dental Caries and Gingival Diseases in 10- to 14-year-old Children: A Cross-sectional Study. Int J Clin Pediatr Dent 2017;10(2):142-146.


  1. Vitamin B12 status of pregnant Indian women and cognitive function in their 9-year-old children. Food Nutr Bull 2008 Dec; 29(4):249-254.
  2. Micronutrient malnutrition, a tragedy to childhood growth and education. Glob J Med Res 2011 May;11(1):27-34.
  3. B12 and folate deficiency: incidence and clinical features. Neurol India 2000 Dec;48(4):302-304.
  4. Signs of impaired cognitive function in adolescents with marginal cobalamin status. Am J Clin Nutr 2000 Sep;72(3):762-769.
  5. Low plasma vitamin B12 in Kenyan school children is highly prevalent and improved by supplemental animal source foods. J Nutr 2007 Mar;137(3):676-682.
  6. High prevalence of cobalamin deficiency in Guatemalan schoolchildren: associations with low plasma holotranscobalamin II and elevated serum methylmalonic acid and plasma homocysteine concentrations. Am J Clin Nutr 2003 Feb;77(2):433-440.
  7. Prevention of dental caries: agents which increase tooth resistance to dental caries. Int Dent J 1972 Dec;22(4):427-440.
  8. Comparative evaluation of trace elements and residual bacterial content of different brands of bottled water. J Indian Soc Pedod Prev Dent 2004 Oct-Dec;22(4):201-204.
  9. Provision of a school snack is associated with vitamin B-12 status, linear growth, and morbidity in children from Bogota, Columbia. J Nutr 2009 Sep;139(9):1744-1750.
  10. The role of nutrition in children's neurocognitive development, from pregnancy through childhood. Front Hum Neurosci 2003 Mar 26;7:97.
  11. Oral manifestations of vitamin B12 deficiency: a case report. J Can Den Assoc 2009 Sep;75(7):533-537.
  12. Micronutrient deficiencies and cognitive functioning. J Nutr 2003 Nov;133(11 Suppl 2):3927S-3931S.
  13. Dental caries and beverage consumption in young children. Pediatrics 2003 Sep;112(3 Pt 1):e184-e191.
  14. The relationship between zinc deficiency and children's oral health. Pediatr Dent 2012 Sep-Oct;34(5):383-386.
  15. Effect of vitamin B12 deficiency on neurodevelopment in infants: current knowledge and possible mechanisms. Nutr Rev 2008 May;66(5):250-255.
  16. Malnutrition and its oral outcome – a review. J Clin Diagn Res 2013 Jan;7(1):178-180.
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